Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The key of epilepsy can be in LGI1/Epitempina gene

07.05.2002


Researchers of the Hospital of San Sebastian and the Biomedicine Institute of Valencia have discovered the genetic basis of hereditary epilepsy. The work leaded by the researchers Adolfo Lopez de Munain and Jordi Perez Tur has analysed the effect of the gene called LGI1/Epitempina.



Temporal lateral epilepsy is the type of epilepsy that affects the side of the brain. The main characteristic of this type of epilepsy is that patients hear some noises before they lose consciousness. Many researcher have located in the 10q24 chromosome the gene related to this disorder. Now, after an immuno-historic research of two families of three generations, they have proved that LGI1 protein has a significant effect in this type of hereditary epilepsy. Moreover, this gene affects the synapse, that is, the connection between neurons. This fact contrasts with other genes responsible of some other hereditary epilepsies which usually affect nerve impulses, because they are receptors of neurotransmitters or ionic canals.

In order to understand the meaning of this discovery, it is necessary to know that epilepsy is not a single disorder, but a set of disorders. This set of disorders causes seizures by common mechanisms. The way to fight against epilepsy is to understand those mechanisms and to use medicines to stop them. The gene called LGI1/Epitempina uses a mechanism which was unknown until now to cause epileptic seizures. Knowing this mechanism is a way to cure other types of epilepsy apart from temporal lateral epilepsy. It must be considered that 80% of epilepsy cases can be treated, but for the rest 20 % there is no adequate medicine. Therefore, any discovery that allows to understand the functioning of epilepsy gives the opportunity to develop new medicines and cures.


Epilepsy is the most common disorder of neurological origin; in fact, 1 % of the population suffers this disorder. A research carried out some years ago stated that 40% of epilepsy cases are hereditary. Nowadays it is believed that this percentage is higher, as in most of the cases epilepsy has genetic components and that makes it hereditary. However, it is not just the case of epilepsy, usually all diseases have a genetic basis. The fact to have this genetic basis does not mean that people with this hobbled gene will necessarily develop the disorder, but that they have more possibilities to develop it.

During the 7 years in which has been carried out the research, scientists of the Basque Country, Italy, Greece, Germany and United Kingdom have participated. The result of the research has been published in the well-known magazine Human Molecular Genetics, in the issue of May, but authors have stated that there is still a long way to go until knowing the mechanism of LGI1/Epitempina.

Garazi Andonegi | alphagalileo

More articles from Health and Medicine:

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

nachricht Study advances gene therapy for glaucoma
17.01.2018 | University of Wisconsin-Madison

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Polymers Based on Boron?

18.01.2018 | Life Sciences

Bioengineered soft microfibers improve T-cell production

18.01.2018 | Life Sciences

World’s oldest known oxygen oasis discovered

18.01.2018 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>