Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Proposal to Step Up Cardio-Vascular Disease Research

22.11.2007
An ambitious European collaboration proposes to set up a new institute to focus funding, coordinate projects, and nurture the requisite skills for accelerating research into cardiovascular disease, the cause of between 30 and 50 percent of the continent's deaths, depending on the country.

The European Vascular Biology Institute (EVBI) is being presented at the annual EuroBioForum conference in Lisbon in December 2007 with a specific brief to convert research into concrete therapies more effectively. EuroBioForum is the annual conference of EuroBioFund, which was established in 2006 to bring together public and private sources of funding to catalyse the development of large scale pan-European life science research programmes. EVBI is one of several major themes being presented at EuroBioForum this year.

The EVBI aims to make another dramatic advance in the fight against cardiovascular disease. Although great progress has been made in recent decades with drugs such as angiotensin converting enzyme inhibitors that reduce blood pressure and statins that reduce cholesterol levels, more sophisticated therapies acting directly at the molecular level are needed to take a further major step forward. The aim is to develop a new generation of drugs that are highly specific in their action.

The EVBI will focus strongly on atherosclerosis, according to one of the institute's main proposers Alain Tedgui, because this is the underlying cause of 80% of all cardiovascular related deaths including myocardial infarction (heart attacks) and strokes, as well as other conditions such as tissue death and organ failure. It occurs to varying degrees in all humans, being a chronic inflammatory disease of the arteries in which atherosclerotic plaques develop, leading ultimately to a variety of complications including blood clotting and loss of blood supply to organs. The EVBI aims both to block progress of atherosclerosis through drug therapies and vaccination, and also to tackle the related diseases, for example via stem cell based therapies to repair the heart after myocardial infarction.

Fortunately the EVBI does not have to start from a clean slate, but proposes to build on existing projects, and in particular the European Vascular Genomics Network (EVGN), which has been running since January 2004 as part of the European Commission's FP6 framework research programme. EVGN has been promoting multidisciplinary interaction between 30 world class basic and clinical institutions in 11 European countries. The EVBI will harness this work. "The EVBI sets a milestone for our perpetuation strategy," said Catherine Clusel, the Project Manager of EVGN. This is also where the EuroBioFund comes in, Clusel added. "It will allow us to present the existing framework to potential funders, including on one side the pharmaceutical companies involved in the elaboration of the Strategic Research Agenda (SRA) for the Innovative Medicines Initiative, and on the other side the European public or private foundations that are eager to support the most prestigious high profile research groups working in this area in Europe. EVBI addresses bottlenecks identified within the SRA for safety and efficacy in inflammatory diseases with an emphasis on atherosclerosis, and unites the European key opinion leaders in cardiovascular disease."

On the scientific front, EVBI will exploit existing project platforms, notably the EVGN's Zebrafish animal model, which allows vascular disease progression and the action of therapies to be monitored and analysed closely. The aim is to build on these platforms within an integrated and ongoing programme, said Clusel, providing secure long lasting funding with the aim of keeping Europe at the forefront of this crucial area of medical research.

Thomas Lau | alfa
Further information:
http://www.esf.org/eurobiofund

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>