The European Vascular Biology Institute (EVBI) is being presented at the annual EuroBioForum conference in Lisbon in December 2007 with a specific brief to convert research into concrete therapies more effectively. EuroBioForum is the annual conference of EuroBioFund, which was established in 2006 to bring together public and private sources of funding to catalyse the development of large scale pan-European life science research programmes. EVBI is one of several major themes being presented at EuroBioForum this year.
The EVBI aims to make another dramatic advance in the fight against cardiovascular disease. Although great progress has been made in recent decades with drugs such as angiotensin converting enzyme inhibitors that reduce blood pressure and statins that reduce cholesterol levels, more sophisticated therapies acting directly at the molecular level are needed to take a further major step forward. The aim is to develop a new generation of drugs that are highly specific in their action.
The EVBI will focus strongly on atherosclerosis, according to one of the institute's main proposers Alain Tedgui, because this is the underlying cause of 80% of all cardiovascular related deaths including myocardial infarction (heart attacks) and strokes, as well as other conditions such as tissue death and organ failure. It occurs to varying degrees in all humans, being a chronic inflammatory disease of the arteries in which atherosclerotic plaques develop, leading ultimately to a variety of complications including blood clotting and loss of blood supply to organs. The EVBI aims both to block progress of atherosclerosis through drug therapies and vaccination, and also to tackle the related diseases, for example via stem cell based therapies to repair the heart after myocardial infarction.
Fortunately the EVBI does not have to start from a clean slate, but proposes to build on existing projects, and in particular the European Vascular Genomics Network (EVGN), which has been running since January 2004 as part of the European Commission's FP6 framework research programme. EVGN has been promoting multidisciplinary interaction between 30 world class basic and clinical institutions in 11 European countries. The EVBI will harness this work. "The EVBI sets a milestone for our perpetuation strategy," said Catherine Clusel, the Project Manager of EVGN. This is also where the EuroBioFund comes in, Clusel added. "It will allow us to present the existing framework to potential funders, including on one side the pharmaceutical companies involved in the elaboration of the Strategic Research Agenda (SRA) for the Innovative Medicines Initiative, and on the other side the European public or private foundations that are eager to support the most prestigious high profile research groups working in this area in Europe. EVBI addresses bottlenecks identified within the SRA for safety and efficacy in inflammatory diseases with an emphasis on atherosclerosis, and unites the European key opinion leaders in cardiovascular disease."
On the scientific front, EVBI will exploit existing project platforms, notably the EVGN's Zebrafish animal model, which allows vascular disease progression and the action of therapies to be monitored and analysed closely. The aim is to build on these platforms within an integrated and ongoing programme, said Clusel, providing secure long lasting funding with the aim of keeping Europe at the forefront of this crucial area of medical research.
Thomas Lau | alfa
NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University
How to turn white fat brown
07.12.2016 | University of Pennsylvania School of Medicine
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Health and Medicine
07.12.2016 | Life Sciences
07.12.2016 | Health and Medicine