He came up with a combination of two techniques that were previously considered to be incompatible: the separation technique electrokinetic chromatography (EKC) and the detection technique mass spectroscopy (MS). He has used this approach to develop an extra quality control mechanism for the active ingredient and excipients in medicines. With this, the chance of a toxic substance ending up in a medicine will be reduced considerably.
Mol applied the combined technique he has developed to so-called impurity profiling, during which contaminants in pharmaceutical samples are analysed. It proved possible to measure contaminants in medicines to within the 0.1% (m/m) level, which means the method satisfies all of the official sensitivity requirements.
No more harmful side effects
The combined technique can also help to limit the harmful side effects of medicines. Many medicines consist of several forms that are, as it were, mirror images of each other. One of the mirror images is the active ingredient where as the other can cause side effects. The medicine Softenon is a well-known example of this. The active substance is thought to be harmless but the mirror image of this was possibly the cause of serious birth defects.
The standard technique for determining harmful contaminants in medicines is high pressure liquid chromatography (HPLC). Mol believes that his linking of the separation technique EKC to the detection technique MS is a very good alternative analysis technique for checking the composition of medicines. The sensitivity of the systems is good and it can be used for a wide range of medicines. Mol is not alone in his thinking. Two companies participating in the research, Solvay and Organon, have also expressed particular interest in the systems.
Besides decreasing harm to human lives this will also save costs. In 2006, for example, a side effect of a medicine was reported on more than 6000 occasions - estimated costs for hospital admission: 85 million euros.
Mol’s research was funded by Technology Foundation STW.
Sonja Knols | alfa
A whole-body approach to understanding chemosensory cells
13.12.2017 | Tokyo Institute of Technology
Research reveals how diabetes in pregnancy affects baby's heart
13.12.2017 | University of California - Los Angeles Health Sciences
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
13.12.2017 | Health and Medicine
13.12.2017 | Physics and Astronomy
13.12.2017 | Life Sciences