Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique improves purity of medicines

25.10.2007
Dutch researcher Roelof Mol has investigated possibilities for more accurately determining the composition of medicines.

He came up with a combination of two techniques that were previously considered to be incompatible: the separation technique electrokinetic chromatography (EKC) and the detection technique mass spectroscopy (MS). He has used this approach to develop an extra quality control mechanism for the active ingredient and excipients in medicines. With this, the chance of a toxic substance ending up in a medicine will be reduced considerably.

Mol applied the combined technique he has developed to so-called impurity profiling, during which contaminants in pharmaceutical samples are analysed. It proved possible to measure contaminants in medicines to within the 0.1% (m/m) level, which means the method satisfies all of the official sensitivity requirements.

No more harmful side effects

The combined technique can also help to limit the harmful side effects of medicines. Many medicines consist of several forms that are, as it were, mirror images of each other. One of the mirror images is the active ingredient where as the other can cause side effects. The medicine Softenon is a well-known example of this. The active substance is thought to be harmless but the mirror image of this was possibly the cause of serious birth defects.

The standard technique for determining harmful contaminants in medicines is high pressure liquid chromatography (HPLC). Mol believes that his linking of the separation technique EKC to the detection technique MS is a very good alternative analysis technique for checking the composition of medicines. The sensitivity of the systems is good and it can be used for a wide range of medicines. Mol is not alone in his thinking. Two companies participating in the research, Solvay and Organon, have also expressed particular interest in the systems.

Besides decreasing harm to human lives this will also save costs. In 2006, for example, a side effect of a medicine was reported on more than 6000 occasions - estimated costs for hospital admission: 85 million euros.

Mol’s research was funded by Technology Foundation STW.

Sonja Knols | alfa
Further information:
http://www.nwo.nl/nwohome.nsf/pages/NWOA_77ZFKY_Eng

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

Metallic nanoparticles will help to determine the percentage of volatile compounds

20.10.2017 | Materials Sciences

Shallow soils promote savannas in South America

20.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>