Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Is a good night’s sleep crucial for your health?

23.10.2007
Sleep restriction project - one of the EU funded success stories
In spring 2005 a large European research and training network was established
to investigate the causes and implications of poor sleep from a medical as well as from a social point of view. This EU-financed sleep research project, “The biomedical and sociological effects of sleep restriction”, is coordinated by Dr. Tarja Porkka-Heiskanen (Stenberg) MD, PhD, at the University of Helsinki, Institute of Biomedicine. The other partners are from UK (University of Surrey), Belgium (Université Libre de Bruxelles), Germany (Max Planck Institute for Psychiatry & Center of Mental Health, Klinikum Ingolstadt) and Switzerland (University of Zurich).

The project has now been nominated as one of the 40 “success stories” among EU-funded projects to be show-cased in a publication at the end of this year.

The topic of the project is important and timely: our environment is changing to a 24/7 society, which inevitably means that time spent in sleep decreases. What are the consequences of this reduction for human health and well-being? This is the central question of the present consortium.

The training network consists of 16 young Marie Curie Fellows from 12 countries, who are trained in the six consortium laboratories by experienced mentors. They are researching the role of sleep in the quality of life; in mood disorders, and how it can affect performance, accident rates, and cardiovascular diseases. Animal models complement the project aiming to understand the basic mechanisms underlying sleep regulation and thereby provide recommendations for the development of new hypnotics.

Although the work is only half way through, interesting results have already emerged. The Helsinki group has investigated the effect of partial sleep loss on human health using an experimental setup that resembles a normal working week. They found that following sleep restriction to 4 hours per night, an individual’s ability to perform complex tasks gradually decreased during the five days. Several changes in their immunological system were also recognized, e.g. increase in CRP (C-reactive protein), an indicator of defense reaction.

The Sociology of Sleep Group at the University of Surrey have shown the diverse ways in which the social context of everyday life has profound influences on sleep quality. Indepth interviews with women in Italy show how women’s sleep is severely disrupted by care-giving roles, especially for frail elderly relatives. Analysis of large-scale surveys has found strong social inequalities in sleep problems with poorer sleep recorded for people living in more disadvantaged social circumstances, such as with low income and low educational attainment. The Chronobiology Group at the University of Surrey have been investigating the effect of blue short wavelength light on circadian rhythms and sleep in the young and elderly. A reduced responsiveness to short wavelength light has been observed in older people and this may have implications for the design of lighting in elderly homes.

The group in Munich and Ingolstadt has first evidence for an influence of a chronic sleep disorder going along with severe sleepiness (narcolepsy) on the processing of emotional stimuli in the brain, suggesting that disturbed sleep regulation profoundly interferes with our well being and the interaction with the environment.

Basic research in the human sleep research laboratory of the University of Zürich revealed clear age-related changes in the impairment of sustained vigilant attention after one night without sleep. This finding is consistent with epidemiological studies and has important implications for the prevention of accidents associated with the loss of sleep.

The group from the University of Zurich, dedicated to animal research, recorded sleep in different mouse models under normal conditions and under enhanced sleep pressure attained by sleep deprivation of a few hours. The effect of pharmacological stimulation of different types of GABAA receptors was investigated. This research aims at opening new avenues for the development of hypnotics. The hypnotic efficacy, when based on normal sleep physiology, should be optimized and lead to less adverse effects.

The mentors recognize the pressing need to bring the results of this research network available to all people. Training of the Fellows includes, in addition to the scientific training, also training in communication with the general public. The Fellows are encouraged to write articles and give general presentations – each of them has written a description of their work, which is available on the website (www.sleep.fi) of the project.

Dr. Porkka-Heiskanen is very pleased that the EU has given this recognition to her project. She explains that “the success of this project was already founded in a previous project where the same consortium members worked together. It cannot be emphasized enough how important these long-term collaborations are. In addition to the high quality science, all mentors are genuinely interested in teaching, and have been actively engaged in development work at their own universities. The enthusiasm for science and the joy of sharing the knowledge is contagious!”

Consortium Members:

University of Helsinki, Finland
Dr. Tarja Porkka-Heiskanen, Team Leader and Coordinator of the project
- coordination of the project
- basic sleep research (extensive experience in using in vivo microdialysis and several other methods of biomedical research)

- imaging

University of Surrey, UK
Prof. Sara Arber, Team Leader, Sociology
- sociological factors influencing the quality of sleep, based on indepth qualitative research and analysis of large-scale representative surveys
Prof. Debra Skene, Team Leader, Chronobiology
- the role of light and the circadian system in sleep mechanisms
- hormonal and metabolic response to sleep deprivation
Unversité Libre de Bruxelles, Belgium
Dr.Myriam Kerkhofs, Team Leader
- human sleep research and biochemical assessment of oxidative stress and of cardiovascular risk factors
Max Planck Institute for Psychiatry, Germany
Center of Mental Health, Klinikum Ingolstadt
Prof. Thomas Pollmächer, Team Leader
- immunological aspects of sleep restriction and treatment of sleep disorders
- influence of sleep disorders on processing of emotional stimuli by the brain
University of Zurich, Switzerland
Prof. Irene Tobler, Team Leader
- basic sleep research in humans and animals and signal analysis of the sleep EEG and mathematical modeling

Paivi Lehtinen | alfa
Further information:
http://www.sleep.fi
http://www.helsinki.fi

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>