The study into the ‘smoking gun’ trail of devastation caused to the body by substances known as ‘free radicals’ will also impact on our understanding of heart disease, neurodegenerative disease and arthritis.
Dr Marcus Cooke, Senior lecturer in the Radiation and Oxidative Stress Section at the University of Leicester, said: “Most of us have heard of free radicals, and the benefits of antioxidants which mop them up - even if it is just from cosmetics commercials“.
“However, premature aging is just the tip of the iceberg for their detrimental effects. Free radicals have been implicated in many diseases. They are arguably the most prevalent cancer causing chemicals known.
“Free radicals are highly reactive, and can cause widespread damage to cells, and in particular DNA - the cell's blueprint. Whilst it is very difficult to measure free radicals themselves, we can measure this damage as a 'smoking gun' signature of free radical activity.
“Being able to accurately and sensitively measure this damage will allow us to:get a better understanding of the role of this damage in disease
“This research is particularly important because it provides validated, non-invasive methods for assessing oxidative stress in humans. Being non-invasive this is ideal for looking in young and old patients.
“It will allow us to develop reference ranges to identify what levels of damage in urine are normal, or abnormal, for clinical application and to develop disease risk/prognostic tests.”
Dr. Cooke has been made PI of a project (Euros 45k) to undertake the Europe-wide validation of a urinary biomarker of oxidative stress.
This is one of two studies where Leicester is playing a lead role. Dr. Mark D. Evans is the Principal Investigator in a Euros 60k study to better understand the sources of biomarkers of oxidative stress in urine.
Both projects are spin-offs from a larger Euros 11 million EU Network of Excellence grant (Environment, Cancer, Nutrition and Individual Susceptibility, ECNIS, www.ecnis.org) of which Professor Peter Farmer, of the Department of Cancer Studies and Molecular Medicine, is the project lead at Leicester. (see link at end of release)
Dr Evans said: “These are projects addressing fundamental questions that have been, for the most part, overlooked. Being awarded these two complimentary projects, back-to-back gives us the unique opportunity to address questions that we, and others in the scientific community, have wanted to examine for many years. Likewise, this project incorporates worldwide collaborations between Leicester, Collegium Medicum in Bydgoszcz, Poland; DKFZ (the German Cancer Institute), Heidelberg, Germany; Institute of Cancer Research Sutton, U.K; Medical Institute of Bioregulation, Fukuoka, Japan; and Department of Toxicogenetics, University of Leiden, The Netherlands.
Dr Cooke said: “This is a further reflection of the international status of our group within the free radical and biomonitoring community. Through these projects, we are working closely with many of the top research institutes worldwide.”Dr Cooke said Leicester would act as the hub of a worldwide network of more than 17 laboratories comparing methods of measuring damage to DNA, in urine: “Once we have agreement between methods, we can apply these methods to the study of DNA damage in disease.
Ather Mirza | alfa
Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital
New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
12.12.2017 | Ecology, The Environment and Conservation
12.12.2017 | Ecology, The Environment and Conservation
12.12.2017 | Physics and Astronomy