Curtis Donskey and colleagues from the Cleveland Veterans Affairs Medical Center, Ohio, US, collected stool samples from inpatients and analysed these for S. aureus. The researchers also took samples from the patients’ nostrils, armpits and groins, as well as surrounding surfaces such as bed rails and bedside tables using a moist cotton swab. To determine whether these bacteria would be transferred to the researchers’ hands they bravely touched each of the skin and environmental sites with one hand previously disinfected with an alcohol hand rub. Handprints in agar jelly before and after testing were used to determine the presence of bacterial transfer.
The study’s most important finding was that patients harbouring S. aureus in both their intestines and noses were significantly more likely than those with this bacterium in their nostrils alone to have positive skin cultures. There was also a statistically non-significant trend toward contaminating surrounding surfaces and bacterial transfer to the investigator’s hands.
Cultures from environmental surfaces yielded an average of 12.7 colonies with a range of 1 to 80, while cultures from armpits and groins yielded colonies of bacteria “too numerous to count.” Hand cultures after contact with environmental and skin surfaces yielded an average of 15.3 colonies with a range of 1 to 80. Most of the patients colonized with S. aureus had the MRSA (Methicillin-resistant Staphylococcus aureus) strain, which is unaffected by treatment with certain antibiotics.
“Because staphylococci on skin may contaminate devices or wounds and be acquired on hands, our data provide support for the hypothesis that colonization of the intestinal tract may facilitate S. aureus infections and nosocomial transmission,” Donskey says.
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
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23.05.2017 | Event News
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26.05.2017 | Life Sciences
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