Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Risk stratification in acute heart failure New insights into the management of acute failure

03.09.2007
Hospitalization for acute heart failure is the most relevant burden for the health systems in both Europe and North America. Despite its dramatic impact on patient survival, quality of life and health costs, relatively few studies have been conducted in patients with this clinical condition in order to identify effective therapeutic strategies able to improve not only symptoms but also patient survival.

Differently from myocardial infarction that has comparable incidence and short term mortality, risk stratification models for patient with acutely decompensated heart failure are not available for current clinical practice. The identification of clinical variables able to predict short-term prognosis may be very helpful in guiding medical decision making including the need of a more intensive management in an intensive or a coronary care unit.

The EuroHeart Survey on Heart Failure collected data on 3,579 patients admitted acutely for heart failure by 133 centres in 30 countries. We excluded from this analysis the patients with cardiogenic shock, whose short-term mortality is so high that specific models for risk stratification are less useful since an intensive management is needed in all patients.

The database of the remaining 3,441 patients included in the EuroHeart Survey on Heart Failure showed that in-hospital all-cause mortality of patients with acute decompensation of an already known heart failure condition was 5.3% (116/2202 patients), while total in-hospital mortality of patients with de novo acute heart failure was 5.4% (67/1239 patients).

Even if overall mortality was 5.3%, the mortality risk greatly varied from less than 1% to more than 50% according to the presence or absence of clinical variables that significantly influence in-hospital death. In both situations (worsening or de novo heart failure), the strongest independent predictors of short-term all-cause mortality were the following ones: advanced age, low systolic blood pressure, renal dysfunction, signs of peripheral hypo-perfusion and an acute coronary syndrome as precipitating factor for heart failure. With the exception of age, all these clinical conditions can be appropriately and timely managed to reduce in-hospital mortality.

These simple clinical variables, easy to detect in any clinical setting, can be very helpful in the identification of patients at high risk of early death after hospital admission for acute heart failure, allowing a tailored use of intensive therapeutic strategies including the setting (intensive vs usual) in which the patients may be more appropriately managed.

ESC Press Office | alfa
Further information:
http://www.escardio.org

More articles from Health and Medicine:

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

nachricht Camouflage apples
22.03.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Pulverizing electronic waste is green, clean -- and cold

22.03.2017 | Materials Sciences

Astronomers hazard a ride in a 'drifting carousel' to understand pulsating stars

22.03.2017 | Physics and Astronomy

New gel-like coating beefs up the performance of lithium-sulfur batteries

22.03.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>