Differently from myocardial infarction that has comparable incidence and short term mortality, risk stratification models for patient with acutely decompensated heart failure are not available for current clinical practice. The identification of clinical variables able to predict short-term prognosis may be very helpful in guiding medical decision making including the need of a more intensive management in an intensive or a coronary care unit.
The EuroHeart Survey on Heart Failure collected data on 3,579 patients admitted acutely for heart failure by 133 centres in 30 countries. We excluded from this analysis the patients with cardiogenic shock, whose short-term mortality is so high that specific models for risk stratification are less useful since an intensive management is needed in all patients.
The database of the remaining 3,441 patients included in the EuroHeart Survey on Heart Failure showed that in-hospital all-cause mortality of patients with acute decompensation of an already known heart failure condition was 5.3% (116/2202 patients), while total in-hospital mortality of patients with de novo acute heart failure was 5.4% (67/1239 patients).
Even if overall mortality was 5.3%, the mortality risk greatly varied from less than 1% to more than 50% according to the presence or absence of clinical variables that significantly influence in-hospital death. In both situations (worsening or de novo heart failure), the strongest independent predictors of short-term all-cause mortality were the following ones: advanced age, low systolic blood pressure, renal dysfunction, signs of peripheral hypo-perfusion and an acute coronary syndrome as precipitating factor for heart failure. With the exception of age, all these clinical conditions can be appropriately and timely managed to reduce in-hospital mortality.
These simple clinical variables, easy to detect in any clinical setting, can be very helpful in the identification of patients at high risk of early death after hospital admission for acute heart failure, allowing a tailored use of intensive therapeutic strategies including the setting (intensive vs usual) in which the patients may be more appropriately managed.
ESC Press Office | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy