Dr Benjamin Tang, University of Western Sydney, Sydney, Australia, and colleagues based their findings on a meta-analysis (a pooled analysis of previous trials) of 17 studies featuring 52625 people all aged over 50 years, with an average treatment time of 3.5 years. They found that where the compliance rate was high (i.e. patients were sticking to the dosing regimen correctly), there was a 24% fracture risk reduction.
The risk reductions were better with calcium doses of over 1200mg compared with doses of less than 1200mg (20% versus 6% reduction), and with vitamin D doses of 800 IU (international units) or more than with does less than 800IU (16% reduction versus 13% reduction). The treatment effect was also greater in individuals who were elderly, lived in institutions, had a low bodyweight, had a low calcium intake, or were at a higher baseline risk than other individuals. The authors believe those in institutions may have benefited more due to assistance complying with the dosing regimen, eg. by nurses making sure patients took their supplements when required.
In a separate part to the study, the researchers did a meta-analysis of 23 trials that reported bone density as an outcome, and found that calcium supplementation alone, or in combination with vitamin D supplementation also reduced the rate of bone loss at the hip by 0.54% and at the spine by 1.19%.
The authors conclude: “Our meta-analysis has shown that calcium supplementation, alone or in combination with vitamin D, is effective in the preventive treatment of osteoporotic fracture… poor compliance is a major obstacle to obtaining the full benefit of calcium supplementation.”
They add: “Although addition of vitamin D supplementation was not shown to offer additional risk reduction over and above the use of calcium alone, a significant difference was observed between the effects of different vitamin D doses.”
In an accompanying Comment, Dr Jean-Yves Reginster, Bone and Cartilage Metabolism Unit, Liege, Belgium, says: “Unlike previous meta-analyses, Tang provides clear answers to several questions which could be of immediate practical importance for the daily management of osteoporosis….Tang and colleagues contribution is important because it paves the way for future research aiming at the best clinical, pharmacological, and economic optimisation of the use of calcium and vitamin D in patients at increased risk of osteoporotic fractures.”
Tony Kirby | alfa
Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania
The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering