Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Large burns open up a can of worms

23.08.2007
Large burns can trigger cardiac problems and enhanced inflammatory and hypermetabolic responses in patients, a study in the online open access journal Critical Care suggests. Effective treatments may need to focus on these multiple aspects.

Burns trigger an immediate, dramatic inflammatory response, as well as a more delayed and longer-lasting hypermetabolic one. The latter can cause depletion of essential proteins, reduced bone density and muscle strength, and can compromise the function of vital organs. But whilst it’s well known that increased burn size leads to increased mortality in burned patients, the roles played by inflammation and hypermetabolism are less clear.

Marc G. Jeschke from Shriners Hospitals for Children, Texas, USA and colleagues conducted a prospective clinical trial of 189 paediatric burned patients over nine years to see if burn size is associated with differences in inflammation, body composition, protein synthesis and organ function.

Burn injuries involving more than 80% of the total body surface cause marked and prolonged inflammation, increases in hypermetabolism, catabolism, cardiac dysfunction and subsequently higher incidences of infection, sepsis and death. These effects were burn size-dependent. Another outstanding finding was that effect of burn size on cardiac dysfunction. Only large burns caused cardiac dysfunction which was shown by Pereira et al. as one of the major contributor to mortality, implying the importance of adequate cardiovascular support and treatment.

Patients with larger burns also had higher levels of pro-inflammatory cytokines, such as Tumor Necrosis Factor and Interleukin-8. The authors think these give the inflammatory response an added boost, enhancing catabolism and hypermetabolism.

Charlotte Webber | alfa
Further information:
http://www.biomedcentral.com

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

Liver Cancer: Lipid Synthesis Promotes Tumor Formation

12.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>