Stroke is the result of an infarction, or bleeding, within the brain, and it may lead to impaired movement, impaired sensation, and difficulties in cognitive function and speech. Approximately 30,000 people are affected by stroke each year in Sweden, and it is the most common cause of long-term dependence on care.
"Researchers all over the world are intensively searching for new treatments. One interesting possibility is that of activating stem cells in the damaged brain such that the brain can be repaired and regain its function", says stem cell researcher Jonas Faijerson.
Stem cells are immature cells that reside in selected regions of the adult brain. These cells can develop either into nerve cells or into other cells that are important in the brain, such as astrocytes. Astrocytes are the most abundant cell type in the brain, and they play an important role when the brain is damaged.
The dissertation shows that activated astrocytes release substances that activate stem cells within the brain.
"We have shown that a very interesting hormone known as 'TRH' is released in large amounts after a stroke, and that this hormone can not only protect from damage but also lead to the activation of stem cells", says Jonas Faijerson.
The stem cells also release survival factors to the surrounding brain tissue when the brain is injured or diseased. The dissertation describes the identification of a completely unknown survival factor, which the researchers have named "pentinin".
"Pentinin protects brain cells from several of the effects that a stroke causes. Both TRH and pentinin are interesting candidates for the development of new treatment strategies for patients with stroke. It is possible that these substances could be given in tablet form, as a drop, or as a nasal spray, when a stroke is suspected", says Jonas Faijerson.
The research has been carried out at the Centre for Brain Repair and Rehabilitation at the Sahlgrenska Academy.
"This work was supervised by a revered friend and colleague, the late Peter Eriksson", says Jonas Faijerson.
Dissertation submitted for the degree of Ph. D. in Medicine at the Sahlgrenska Academy, Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and Rehabilitation
Title of the dissertation: Neural Stem/Progenitor cells in the Post-ischemic Environment: Proliferation, Differentiation and Neuroprotection
The dissertation has been successfully defended.
For more information, contact: Jonas Faijerson, stem cell researcher, telephone: +46 31 786 3438 Mobile: +46 70 881 1231, e-mail: firstname.lastname@example.org
Elin Lindström Claessen | idw
Improving memory with magnets
28.03.2017 | McGill University
Graphene-based neural probes probe brain activity in high resolution
28.03.2017 | Graphene Flagship
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
28.03.2017 | Life Sciences
28.03.2017 | Information Technology
28.03.2017 | Physics and Astronomy