Professor Geert Leroux-Roels, Centre for Vaccinology, Ghent University and Hospital, Belgium and colleagues report on an “antigen sparing adjuvant strategy”, which, by combining the vaccine with an oil-in-water emulsion “adjuvant”, allows the body to produce up to six times as many bird influenza virus neutralising antibodies as it would with an non-adjuvanted vaccine with the same dose.
The bird flu strain H5N1 is widely regarded as the probable cause of the next global influenza pandemic. This virus contains a H5 haemagglutinin antigen subtype, which generally produces a poor immunogenic response in humans and to which most of the world population is immunologically naïve. As a result, the one-dose schedule routinely used for seasonal “regular” influenza vaccines is unlikely to be sufficient to give immunity. The authors say: “Clearly, new formulations that require less antigen per dose are needed. The use of adjuvant to improve immunogenicity is a crucial antigen-sparing strategy.”
The researchers did a study of eight groups of 50 volunteers aged 18-60 years, and studied four antigen doses (3.8µg, 7.5µg, 15µg, 30µg haemagglutinin) given with or without the oil-water adjuvant. Blood samples were then collected to analyse the immune response, and the results showed that the adjuvanted formulations were significantly more immunogenic than the non-adjuvanted formulations at all doses. All eight vaccine formulations had good safety profiles, although the adjuvanted vaccines produced more injection-site symptoms and general symptoms (most of which were mild to moderate and transient) than the non-adjuvanted vaccines.
The authors say that the ability of the 3.8µg dose of the adjuvanted vaccine to induce cross-immunity against the clade two* H5N1 Indonesia strain in more than the three-quarters of individuals with neutralising titres which are six times higher than the non-adjuvanted formulation “represents significant antigen sparing that could increase the number of recipients of the pandemic influenza vaccine.”
They conclude: “The cross-clade neutralising antibody responses recorded imply that such a vaccine could be deployed before pandemic outbreak, which is an important mitigation strategy proposed for pandemic influenza.”
In an accompanying Comment, Dr Suryaprakash Sambhara, Centers for Disease Control and Prevention, Atlanta, Georgia, USA and Dr Gregory Poland, Mayo Clinic and Foundation, Minnesota, USA, say: “Leroux-Roels and colleagues’ study is the first to show significant antigen dose-sparing, high levels of immunogenicity in association with a novel adjuvant, and the induction of cross-clade immunity against A/H5N1 viruses. Their study lends support for considering a strategy of immunising some groups with prepandemic vaccines for preparedness in the event of a pandemic from an H5N1 virus. This vaccine appears to be an important step forward in our ability to protect against the pandemic threat posed by highly pathogenic influenza A/H5N1 viruses.”
Tony Kirby | alfa
Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences
What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy