Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Restricting blood flow in the arm to protect the heart?

17.08.2007
Patients having the blood supply in their arm restricted temporarily prior to coronary artery bypass graft surgery could have improved outcomes following such surgery, conclude authors of an Article published in this week’s Cardiology Special Issue of The Lancet. And an accompanying comment says that the implications of this for clinical practice “are immense.”

Professor Derek Yellon, The Hatter Cardiovascular Institute, University College London, UK and colleagues studied 57 patients undergoing elective coronary artery bypass graft surgery. Of these, 27 received remote ischaemic preconditioning, namely three five-minute cycles of having the blood flow in one arm restricted using an automated cuff-inflator, with a five-minute periods between each cycle where the cuff was deflated.

The other 30 patients acted as a control group. All patients had the amounts of troponin T in their blood measured before surgery and at 6, 12, 24, 48 and 72 hours after surgery. Troponin T is a cardiac protein which can be released into the bloodstream following the “injury” to the heart during surgery, and release of such proteins is associated with poor short- and long-term clinical outcomes after surgery.

The researchers found the total troponin T released 72 hours after surgery was reduced from 36.12 µg/l in the control group to 20.58 µg/l in the remote ischaemic preconditioning group, a reduction of 43%.

The authors say: “Our study has shown that remote ischaemic preconditioning, mediated by transient upper limb ischaemia, can reduce troponin T in the perioperative period in adult patients undergoing elective coronary artery bypass graft surgery…One might expect that in high-risk patients for whom serum troponin T concentrations are substantially greater, remote ischaemic preconditioning might confer an even greater reduction in myocardial injury.”

In the accompanying Comment, Dr Henry Purcell and Professor John Pepper, Royal Brompton Hospital, London, UK say: “Clearly the technique for remote ischaemic preconditioning needs to be duplicated by equally skilled workers in other cardiac centres in large numbers of patients. In the meantime, if intermittent limb occlusions are consistently shown to reduce myocardial injury during cardiac revascularisation, the implications for practice are immense.”

Tony Kirby | alfa
Further information:
http://www.thelancet.com/webfiles/images/clusters/thelancet/press_office/coronaryartery.pdf

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>