Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Using MRI For Diagnosis Could Help Prevent Breast Cancer Progression

10.08.2007
Using magnetic resonance imaging (MRI) to diagnose breast cancer in its intraductal stage could help prevent the development of invasive cancer, conclude authors of an Article in this week’s edition of The Lancet. And an accompanying Comment says that the findings show that MRI should now be used as a distinct method in its own right to detect breast cancer in its earliest stage.

Professor Christiane Kuhl, Department of Radiology, University of Bonn, Germany and colleagues studied 7319 women over a five-year period who had been referred to an academic breast centre. The women received MRI in addition to conventional mammography for diagnostic assessment and screening, with the aim of discovering the sensitivity of each method for diagnosing ductal carcinoma in situ (DCIS). Mammograms and MRI scans were then assessed independently by different radiologists, and the relative sensitivity of each method of detection was assessed by comparing the biological profiles of mammography-detected DCIS with those of MRI-detected DCIS.

The researchers found that of 167 women who had a diagnosis of DCIS, 153 (92%) were diagnosed by MRI compared with 93 (56%) diagnosed by mammography. Whereas the sensitivity of MRI for diagnosing DCIS increased with nuclear grade, that of mammography decreased. Of 89 women diagnosed with “high grade” DCIS, 87 (98%) were diagnosed by MRI, but only 46 (52%) by mammography. Accordingly, almost half (48%) were missed by mammography but diagnosed by MRI alone. They also found that age, menopausal status, personal or family history of breast cancer, and breast density of women with MRI-only diagnosed disease did not differ significantly from those of women with mammography-diagnosed DCIS. The higher sensitivity of MRI was not associated with an unduly high number of false positive diagnoses - the positive predictive value of both methods was comparable, with 55% for mammography, and 59% for MRI.

The authors conclude: “Our study suggests that the sensitivity of film screen or digital mammography for diagnosing DCIS is limited…MRI could help improve the ability to diagnose DCIS, especially DCIS with high nuclear grade.”

In the accompanying Comment, Dr Carla Boetes and Dr Ritse Mann, Radboud University Nijmegen Medical Centre, Netherlands, say: “These findings can only lead to the conclusion that MRI outperforms mammography in tumour detection and diagnosis. MRI should thus no longer be regarded as an adjunct to mammography but as a distinct method to detect breast cancer in its earliest stage. A large-scale multicentre breast-screening trial with MRI in the general population is essential.”

Tony Kirby | alfa
Further information:
http://www.thelancet.com/webfiles/images/clusters/thelancet/press_office/MRI.pdf

More articles from Health and Medicine:

nachricht Laser activated gold pyramids could deliver drugs, DNA into cells without harm
24.03.2017 | Harvard John A. Paulson School of Engineering and Applied Sciences

nachricht What does congenital Zika syndrome look like?
24.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>