Individual damage caused by arsenic
There are major differences in the ability to metabolise arsenic in the body. This applies both to between different populations and at individual level. Some differences can be explained by factors such as age, gender, exposure levels and genetic make-up. This is shown by a doctoral thesis by Anna-Lena Lindberg of Karolinska Institutet.
The studies included two different populations: one from Central Europe (Hungary, Rumania and Slovakia) and one from Bangladesh (the Matlab area). The results show that most people in the Matlab area and a large number of those in certain parts of Hungary are exposed to high contents of arsenic in their drinking water.
There were big differences in metabolic capacity between individuals in both Europe and Bangladesh. In Bangladesh this was partially explainable by the high exposure level. In Europe it was various genetic factors that had the biggest effect. Age, gender and smoking also came into play. Children, for example, metabolised arsenic better than did adults.
"It's important," Anna-Lena Lindberg emphasises," to try and identify sensitive groups of the population so as to reduce the adverse consequences of arsenic exposure. As the factors I have studied can only explain about a fifth of the variation between individuals, there is a great need to proceed with looking for further factors."
Arsenic occurs naturally in drinking water in certain parts of the world, and millions of people are exposed to high contents. It is carcinogenic, can also contribute to diabetes and cardiovascular diseases and can affect the lungs, liver and nervous system. Arsenic is metabolised in the body and is largely eliminated through the urine - in part as monomethylated arsenic (MA) and in part as dimethylated arsenic (DMA), which is the end product.
The these: Factors influencing the metabolism of inorganic arsenic in humans.
For further information please contact:
Anna-Lena Lindberg, MD
Institute of Environmental Medicine, Unit for Metals and Health
Tel: +46 (0)8-524 874 06
Mobil: +46 (0)70-270 95 45
Sabina Bossi, Press Officer
Tel.: +46 (0)8-524 860 66
Mob.: +46 (0)70-614 860 66
Sabina Bossi | idw
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...