Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HPV Vaccine and Pap Test Both Essential in the Fight Against Cervical Cancer

30.07.2007
The development of the first vaccine for the prevention of cancer came 30 years after Harald zur Hausen first hypothesized that human papilloma virus (HPV) might be associated with cervical cancer.

In those 30 years, much progress has been made in the diagnosis, treatment and now prevention of cervical cancer. In a special issue of Disease Markers, published this month, twelve articles explore the epidemiology of HPV, testing strategies for HPV infections, new HPV detection methods, and other potential biomarkers that might prove useful in cervical cancer diagnosis.

Guest Editors of this special issue, Magnus von Knebel Doeberitz, and Nicolas Wentzensen, both of the University of Heidelberg, have gathered a series of insightful articles that present both historical background and recent research into HPV and cervical cancer. They stress that, “Despite all this success a word of caution: we have not yet reached all the goals. Cervical cancer still is an important public health issue and the prevention approach will only work if at least most women in the world will have access to these vaccines. To achieve this, we will certainly need a lot of efforts and resources. The worst thing to do now would be to neglect the very successful screening programs for cervical cancer that made cervical cancer the prime paradigm for successful cancer prevention strategies.”

Jenkins summarizes the various histo- and cyto-pathological features associated with acute and persistent HPV-infections and provides the reader with the essential knowledge to understand how HPV gene products alter shape and function of normal epithelial cells.

Bosch and de Sanjose present a current and extensive survey of HPV and cervical cancer epidemiology. Moscicki gives an overview of HPV infections, screening, triage, and treatment in adolescents that is highly relevant for vaccination programs, since adolescents represent the primary target population and HPV infection in ever younger girls emerges as a new arising problem. Shah and Westra provide an up-to-date review of HPV associated disease in the aerodigestive tract, including the benign recurrent respiratory papillomatosis as well as head and neck cancers. Nindl and colleagues have summarized biological and clinical data on the role of human papilloma viruses in non-melanoma skin cancer. Palefsky contributes a comprehensive overview of HPV infections in men with respect to disease patterns observed in men, transmission of the virus to women and the related issues concerning the possible vaccination of women and men. Moving towards new approaches in screening, Meijer and colleagues present an extensive survey of different HPV detection methods including genotyping and mRNA detection together with different possible scenarios of their application. Pagliusi contributes an important article on the international standardization of HPV testing.

Further articles address the emerging research on new biomarkers for cervical cancer screening that appear to help to overcome several of the important limitations of the current cancer early detection strategies. Doorbar extensively reviews molecular processes in transition from viral infection to the development of high grade disease and cervical cancer. A special focus is put on the changes of the viral life cycle with effects on cellular genes and proteins. Wentzensen and von Knebel Doeberitz summarize the current state of the most promising biomarkers that have been identified so far for revised cervical cancer screening, triage programs and potential clinical applications. The last two articles deal with the important topic of prophylactic and therapeutic vaccines. Müller and Gissmann contribute an exciting historical essay of the discovery of HPV and the development of therapeutic and prophylactic vaccines. Kast and colleagues present an excellent and very timely survey on therapeutic vaccines against HPV and associated disease with a detailed description of the lessons learned from the limitations of previous vaccination trials and of novel promising approaches.

These articles appear in a special, single-topic issue of Disease Markers, Volume 23:4 (July 2007), published by IOS Press.

Disease Markers, Volume 23:4
HUMAN PAPILLOMAVIRUSES AND CERVICAL CANCER
Guest editors: Magnus von Knebel Doeberitz and Nicolas Wentzensen
Table of Contents
Foreword
M. von Knebel Doeberitz and N. Wentzensen
Histopathology and cytopathology of cervical cancer
D. Jenkins
The epidemiology of human papillomavirus infection and cervical cancer
F.X. Bosch and Silvia de Sanjosé
HPV infections in adolescents
A.-B. Moscicki
Genital HPVs in the aerodigestive tract: Etiologic association with a subset of oropharyngeal/tonsillar cancers and with recurrent respiratory papillomatosis

K.V. Shah and W.H. Westra

Human papillomaviruses and non-melanoma skin cancer: Basic virology and clinical manifestations

I. Nindl, M. Gottschling and E. Stockfleth

HPV infection in men
J.M. Palefsky
HPV detection methods
A.A.T.P. Brink, P.J.F. Snijders and C.J.L.M. Meijer
International standard reagents for HPV detection
S.R. Pagliusi and S.M. Garland
Papillomavirus life cycle organization and biomarker selection
J. Doorbar
Biomarkers in cervical cancer screening
N. Wentzensen and M. von Knebel Doeberitz
A long way: History of the prophylactic papillomavirus vaccine
M. Müller and L. Gissmann
Therapeutic vaccination for HPV induced cervical cancers
J.A. Brinkman, S.H. Hughes, P. Stone, A.S. Caffrey, L.I. Muderspach, L.D. Roman, J.S. Weber and W.M. Kast

Astrid Engelen | alfa
Further information:
http://www.iospress.nl
http://www.iospress.nl/html/02780240.html

More articles from Health and Medicine:

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

nachricht Camouflage apples
22.03.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Pulverizing electronic waste is green, clean -- and cold

22.03.2017 | Materials Sciences

Astronomers hazard a ride in a 'drifting carousel' to understand pulsating stars

22.03.2017 | Physics and Astronomy

New gel-like coating beefs up the performance of lithium-sulfur batteries

22.03.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>