Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Double vaccine against Human Immunodeficient virus

23.07.2007
A vaccine against HIV infections is the most reliable way to stop the AIDS epidemic. A lot of researchers in various countries have been working for more than 20 years to cope with this task. However, the vaccine development is complicated by the fact that human immunodeficiency virus is very changeable, it is able to “hide” from the immune system and causes heavy immunopathologies.

The Novosibirsk researchers have developed a vaccine that is able to cause both humoral and cellular immunity, it means that under the influence of this vaccine, activated cells of the immune system will both form virus antibodies and devour the cells infected by the virus.

The vaccine per se is an artificial virus-like particle. Its capsule consists of the TBI (T- and B cell epitopes containing immunogen) protein constructed by the researchers, the TBI protein being combined with the polyglucin protein. This protein contains 9 participants stimulating different cells of the immune system – both the ones that produce antibodies and the ones that devour the newcomer. The DNA coding the TCI (T-cell immunogen) protein is contained inside the protein coat. The protein contains more than 80 HIV proteins fragments selected in the optimal way, which should activate the immune system.

The researchers have selected only conservative fragments, i.e. the ones that remain constant in the course of all major changes of HIV-1 and will certainly be noticed by the immunize organism. As a matter of fact, the coat and the filling of the particle represent independent vaccines, which cause specific cellular and humoral immune response. In the assembled form, the combiHiVvac vaccine is a particle 40 to 100 nanometers in diameter, approaching in size to the HIV-1 virus.

The antibodies, which are formed by immunized mice under the action of vaccine, recognize the real HIV-1 proteins and neutralize the virus. This was shown by the experiments on the cell culture infected by the virus and processed by mice’s antibodies. Preclinical trial findings allow to hope that the combiHIVvac vaccine will fight efficiently even against modified HIV-1 variants.

The new vaccine is nontoxic. Its single injection to mice even in the fivefold dose does not cause derangements to the organs, and repeated injections reinforce inflammatory processes in the liver, but only in the case if the liver is already out of order. The combiHIVvac vaccine does not cause autoimmune diseases or anaphylactic reactions, it does not weaken the organism’s tolerance to infections either.

The scientists emphasize that as the combiHIVvac vaccine not only stimulates antibody production but also destroys the cells infected by the virus, this vaccine can be considered not only a prophylactic one but also as a therapeutic one. In the Novosibirsk researchers’ opinion, the vaccine they developed is ready for clinical trials.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Electrode materials from the microwave oven

19.10.2017 | Materials Sciences

New material for digital memories of the future

19.10.2017 | Materials Sciences

Physics boosts artificial intelligence methods

19.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>