Parkinson's disease is one of the most widespread neurodegenerative diseases. It develops as a result of injuries of 60 to 80 percent of neurons in a single part of the brain. It is important to find the way to “catch” the disease before neuron degeneration reaches the critical level, and the patient starts suffering from tremor and movement disorders.
To find reliable methods of early diagnostics, the Moscow neurologists examined 12 healthy probationers and 16 patients suffering from the first and the second stages of Parkinson's disease. The participants to the experiment were tested with the help of the hardware and software complex, which analyzes the moving activity. The probationers were (by moving the eyes only) to fix the look on the target, which was shifting across at the angle of 40 degrees. They were suggested to make sliding movements by the head to the left and to the right along the horizontal plane, retaining the look on the target, which moved synchronously with the head movements. And, finally, after several open-eye training sessions, the participants transferred the cursor onto the target by memory, their eyes being curtained off. These three tests allow to check how the patients move separate parts of the body (only eyes, head or hand). In the course of the fourth test, the probationers shifted the cursor from one target to another by moving the eyes, head and hand, i.e. by coordinating their movements.
At the early stage of the disease, individual movements’ indices were changed with the patient, but these changes differed slightly from the age standard. However, all parameters of coordinated movement with Parkinson's disease patients reliably differed from those of healthy probationers. Apparently, at the early stage of the disease, the brain is still able to impede the disease development and to compensate for movement disorders. That is why, although each individual movement occurs with a mistake, the mistake is minimal, and it is not always possible to reveal it. However, in case of coordinated movement all these minor delays, inaccuracies in movements and multistage of movements “superimpose” upon each other, and movement disorders become evident.
The researchers assume that it is the coordinated movement disorder that can be considered as one of the markers for early stage of Parkinson's disease. Analysis of such disorders drastically increases the probability of early disease recognition. Nevertheless, the authors of the hypothesis emphasize that this is only a hypothesis so far, and further experiments are need to verify it.
Nadezda Markina | alfa
Indications of Psychosis Appear in Cortical Folding
26.04.2018 | Universität Basel
GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University
Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...
At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.
Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
26.04.2018 | Power and Electrical Engineering
26.04.2018 | Life Sciences
26.04.2018 | Power and Electrical Engineering