Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Simvastatin – for hearts and minds?

19.07.2007
Statins are not all equal when it comes to their potential to guard against dementia, according to a study published in the online open access journal BMC Medicine.

Statins are cholesterol-lowering drugs used by those with heart disease. The new findings suggest that simvastatin is associated with a lower incidence of dementia and Parkinson’s disease. Disagreement over whether statins could guard against these conditions has meant the benefits to dementia sufferers to date have been unclear.

An international team led by Benjamin Wolozin, MD, at Boston University School of Medicine used data from the US Veterans Affairs Database, which contains diagnostic, medication and demographic information on 4.5 million subjects. The researchers used statistical models to compare different statins, looking at data on over 700,000 simvastatin users and more than 50,000 atorvastatin users. The team targeted those aged 65 or over with no prior diagnosis of Alzheimer’s disease, who had been taking statins for at least seven months.

The researchers found that for subjects aged 65 and over, simvastatin was linked with a significantly reduced number of cases of dementia and Parkinson's disease". The researchers also made the surprising finding that not all statins are equal when it comes to dementia or Parkinson’s disease. A small reduction in dementia cases was seen among those who regularly take atorvastatin, which did not reach a level of statistical significance. Lovastatin was not found to have any significant effect on dementia, and neither atorvastatin nor lovastatin were associated with a reduction in the number of cases of Parkinson’s disease.

“The strength of reduction of incidence of dementia observed with simvastatin is striking,” the authors write. Further studies should confirm that it is simvastatin’s biological mode of action rather than a statistical bias at work. Previous research has studied whether statin treatment is beneficial for dementia sufferers or those at risk of dementia, but such research has lead to some conflicting results. The current study gives more reliable results as it has considerable statistical power and incorporates existing data to investigate dementia and Parkinson’s disease comprehensively.

Charlotte Webber | alfa
Further information:
http://www.biomedcentral.com/bmcmed/

More articles from Health and Medicine:

nachricht Serious children’s infections also spreading in Switzerland
26.07.2017 | Universitätsspital Bern

nachricht New vaccine production could improve flu shot accuracy
25.07.2017 | Duke University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

CCNY physicists master unexplored electron property

26.07.2017 | Physics and Astronomy

Molecular microscopy illuminates molecular motor motion

26.07.2017 | Life Sciences

Large-Mouthed Fish Was Top Predator After Mass Extinction

26.07.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>