Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mouse Study Suggests Blood Test Could Diagnose Alzheimer’s Earlier

25.03.2002


Scientists have developed a blood test that may reveal changes in the brain caused by Alzheimer’s disease. The technique, tested so far only in mice, predicts the amount of amyloid plaque (formed from clumps of proteins that kill surrounding cells) in an animal’s brain. The research, detailed in a report in the current issue of the journal Science, holds promise for the development of predictive methods to diagnose the disease years ahead of the onset of clinical symptoms.



David Holtzman of the Washington University School of Medicine and colleagues worked with mice that had been genetically engineered to develop an Alzheimer’s-like disease. They measured the amount of amyloid-b (Ab) protein in the animals’ blood and found that it did not correlate to the extent of plaque formation in the brain, which is also the case for humans. But when they treated 49 animals with an artificial antibody known as m266, they found that their levels of Ab increased dramatically within as little as five minutes. Moreover, the increased blood levels correlated with the amount of amyloid in two regions of the brain affected by Alzheimer’s, the hippocampus and the cingulate cortex. According to study co-author Ronald B. DeMattos of Washington University School of Medicine, "a simple injection of m266 altered the metabolism of Ab and unmasked important correlations with brain pathology."

Whether the results will apply to humans suffering from Alzheimer’s disease remains unclear. Even if the test does work, it can only diagnose patients who have already started to accumulate amyloid. But as Holtzman notes, "such a test also could distinguish individuals suffering from dementia caused by Alzheimer’s from those with other types of dementia, and may help us evaluate an individual’s response to particular medical therapies."

Sarah Graham | Scientific American

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>