This tradeoff has led to the development of various drug-sparing HIV-1 treatment strategies, which often results in the emergence of resistant viruses and overall treatment failure. This has prompted an interest in induction–maintenance (IM) treatment strategies, in which brief intensive therapy is used to reduce host viral levels, which is then followed by a simplified and more easily tolerated maintenance regimen.
IM approaches remain an unproven concept in HIV therapy. In a study publishing July 13, 2007 in PLoS Computational Biology, clinical responses to antiretroviral drug therapy are simulated for the first time, and the model is then applied to IM therapy. Marcel Curlin, Shyamala Iyer, and John Mittler, from the University of Washington, find that IM is expected to be successful beyond three years and that six to ten months of induction therapy should achieve durable suppression of HIV and maximize the possibility of eradicating viruses resistant to the maintenance regime. They also find the counter-intuitive result that for induction regimens of limited duration the optimal time to initiate induction therapy may be several days or weeks after the start of regular (maintenance) therapy.
These results are important not simply because they show how this particular, albeit important, therapy strategy may be optimized, but because they illustrate the more general potential for mathematical models to influence therapy decisions. “Our experience has been that clinicians and policy makers are often hesitant to consider, sometimes even hostile towards, mathematical modeling approaches. Instead, they rely on intuition or await the results of expensive, long-term clinical trials”, says Mittler. By presenting a detailed model that makes concrete quantitative predictions and gives some interesting, counter-intuitive qualitative results, this paper may help to change attitudes concerning the value of dynamical modeling approaches.
PLEASE ADD THIS LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0030133 (link will go live on July 13th)
CITATION: Curlin ME, Iyer S, Mittler JE (2007) Optimal timing and duration of induction therapy for HIV-1 Infection. PLoS Comput Biol 3(7): e133. doi:10.1371/journal.pcbi.0030133CONTACT:
Andrew Hyde | alfa
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy