Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique for detecting cardiac fibrosis

21.03.2002


A medical team of the Basque Country has discovered a new technique to detect cardiac fibrosis. After a research carried out during several years, it has been discovered that serum leves of PIP peptide is an indicator of increased myocardial fibrosis.



Fibrosis is formed when scar tissue is accumulated in heart. As a consequence it causes stiffening of the heart and often heart failure. In order to fight against such disease, researchers started looking for an indicator substance in blood.

Collagen amount and PIP


This research started 10 years ago with spontaneoulsy hypertensive rats. As a result, they could find out that hypertensive disease increases the amount of heart collagen. On the other hand, researchers did know that in some other diseases, like cirrhosis of the liver, collagen amount used to increase. It was also well known that in such disease the serum amount of PIP substance (carboxyterminal peptide of type 1 procollagen) was high. Hence, could it be possible that this peptide shows also which patientes are accumulating too much scar tissue in the heart?

The research carried out in rats confirmed that. The amount of peptide was clearly higher in those rats who had abnormal myocardial fibrosis than in those who did not. However, the result had to be tested in human beings. To do that, they did blood analysis and endomyocardial biopsies in hypertensive patients and found that in these patients myocardial collagen content was 4-5 times higher than in normotensive subjects and was closely correlated with serum levels of PIP.

Successful results

This new indicator, PIP substance, can successfully detect fibrosis in 80% of the cases. That is a great step forward considering the detection rate of the existing techniques. Now, in order to apply this technique, measures of PIP must be carried out in more patients. However, it has been proved that cardiac fibrosis is caused by hypertension and that it can be detected thanks to PIP peptide.

Moreover, analysing treatments to lower high blood pressure, they find out that some of the used medications which counteract the effects of a substance called angiotensin II, had a backward effect on fibrosis. This backward effect was observed in PIP substance aswell. Therefore, apart from indicating the presence of the disease and showing its severity, it may be used to assess the capability of antihipertensive medications to repare myocardial structure.

Future researches will be focused on physiological and pathological relationship between heart failure, fibrosis and high blood pressure. Then it may be possible to find prevention pathways of heart failure, which is widely prevalent in our age-increasing society.

Carton Eider | alphagalileo

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>