Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New technique for detecting cardiac fibrosis

21.03.2002


A medical team of the Basque Country has discovered a new technique to detect cardiac fibrosis. After a research carried out during several years, it has been discovered that serum leves of PIP peptide is an indicator of increased myocardial fibrosis.



Fibrosis is formed when scar tissue is accumulated in heart. As a consequence it causes stiffening of the heart and often heart failure. In order to fight against such disease, researchers started looking for an indicator substance in blood.

Collagen amount and PIP


This research started 10 years ago with spontaneoulsy hypertensive rats. As a result, they could find out that hypertensive disease increases the amount of heart collagen. On the other hand, researchers did know that in some other diseases, like cirrhosis of the liver, collagen amount used to increase. It was also well known that in such disease the serum amount of PIP substance (carboxyterminal peptide of type 1 procollagen) was high. Hence, could it be possible that this peptide shows also which patientes are accumulating too much scar tissue in the heart?

The research carried out in rats confirmed that. The amount of peptide was clearly higher in those rats who had abnormal myocardial fibrosis than in those who did not. However, the result had to be tested in human beings. To do that, they did blood analysis and endomyocardial biopsies in hypertensive patients and found that in these patients myocardial collagen content was 4-5 times higher than in normotensive subjects and was closely correlated with serum levels of PIP.

Successful results

This new indicator, PIP substance, can successfully detect fibrosis in 80% of the cases. That is a great step forward considering the detection rate of the existing techniques. Now, in order to apply this technique, measures of PIP must be carried out in more patients. However, it has been proved that cardiac fibrosis is caused by hypertension and that it can be detected thanks to PIP peptide.

Moreover, analysing treatments to lower high blood pressure, they find out that some of the used medications which counteract the effects of a substance called angiotensin II, had a backward effect on fibrosis. This backward effect was observed in PIP substance aswell. Therefore, apart from indicating the presence of the disease and showing its severity, it may be used to assess the capability of antihipertensive medications to repare myocardial structure.

Future researches will be focused on physiological and pathological relationship between heart failure, fibrosis and high blood pressure. Then it may be possible to find prevention pathways of heart failure, which is widely prevalent in our age-increasing society.

Carton Eider | alphagalileo

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>