Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers isolate new risk marker for overweight children

25.06.2007
A study of 40 overweight children in Edmonton has revealed they all share something in common aside from being heavy: each one of them has high levels of apoB48, a structural protein found in intestinal cholesterol.

The children displayed high levels of apoB48 even as their LDL cholesterol levels, which are typically high in overweight adults, remained in the normal range.

In discovering high levels of apoB48 in these children, the researchers believe they've found a new and important clue to better understand how some adults are more susceptible to cardiovascular disease (CVD) than others.

"We don't consider these children to be at risk of developing CVD right now. But they have indicated apoB48 at levels that are the same as those that appear in adults who are considered at high risk; so, unless their levels decrease, they will become high risk as they age," said Dr. Spencer Proctor, a nutritional scientist at the U of A and a co-author of the study.

However, testing for apoB48 is currently rare, difficult and expensive, Proctor said.

The prevailing wisdom among researchers is that high LDL cholesterol, which is produced in the liver, is the best indicator of a patient's CVD risk, even though researchers struggle to explain why 40 to 50 per cent of people who suffer cardiac episodes have "normal" LDL levels.

Proctor and his colleagues, including U of A obesity researcher Dr. Geoff Ball, believe that apoB48, which is found exclusively in a type of cholesterol produced in the intestine called chylomicrons, may complement LDL cholesterol as a marker that doctors should look for when gauging a patient's risk of developing CVD.

"We are not measuring the right things and not understanding all the processes that cause CVD," Proctor said. "This study adds to a growing body of evidence we've collected that indicates measuring apoB48 levels as a means to measure chylomicron levels may be an important piece to the puzzle in understanding just who is and who isn't at risk of CVD."

Proctor believes testing for apoB48 may become more common and less expensive as people realize how important it is in determining CVD risk.

And while Proctor and his colleagues believe chylomicrons contribute significantly to the development of CVD, they feel more tests need to be done to find out why. They currently don't know if a diet of sugary, high-fat foods is the sole cause of high levels of apoB48 in children or if high levels of apoB48 are the result of a genetic imbalance that does not allow some people to metabolize sugary, high-fat foods adequately.

"Right now we think it's probably a combination of both a poor diet and genetics that make a person produce high levels of apoB48," Proctor said.

He added that as we learn more about the effect of intestinal cholesterol, we will be better prepared to prescribe treatments to prevent CVD.

"For some people exercise and diet changes may be the best prescription, for others it may be a pharmaceutical intervention, and, indeed, in some cases a combination of both may be required," Proctor said, adding that pharmaceutical companies are currently on the cusp of producing new drugs that target the reduction of chylomicron cholesterol.

"We already know that it's not simply how much you weigh that makes you susceptible to CVD. It's also how much fat you have and the type of fat you have that is important," Proctor said. "A marker such as apoB48 may be just the clue we need to determine whether or not you are at risk, and, if you are, the best methods we can prescribe to reduce the risk, particularly in our young population as they grow older."

Ryan Smith | EurekAlert!
Further information:
http://www.ualberta.ca

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

Achema 2018: New camera system monitors distillation and helps save energy

22.05.2018 | Trade Fair News

VideoLinks
Science & Research
Overview of more VideoLinks >>>