Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Combating infectious disease with probiotics

18.06.2007
Scientists at University College Cork have discovered that probiotic bacteria can protect against bacterial infection. The work was carried out in the Alimentary Pharmabiotic Centre (APC) in UCC, published recently in the prestigious scientific journal, the Proceedings of the National Academy of Sciences. In fact, an image based on the work of the group was also chosen to illustrate the cover of the journal, a significant achievement for the UCC-based team.

The APC, funded by Science Foundation Ireland, was set up investigate the beneficial roles of the bacteria found in the gastro-intestine of healthy humans. The research group examined a range of beneficial bacteria and found one specific probiotic bacterium (Lactobacillus salivarius UCC118) which was able to kill Listeria monocytogenes, an often lethal pathogen in pregnant women. The probiotic kills the pathogen by producing an antibiotic-like compound called a bacteriocin.

Tests showed that Lactobacillus salivarius offered significant protection against Listeria infection but that a strain of non-bacteriocin producing Lactobacillus generated by the researchers did not. The results of the UCC work clearly demonstrate a role for bacteriocins in protecting the host against potentially lethal infections. The study is the first to clearly demonstrate a mechanism by which probiotic bacteria may act to help improve the health of consumers.

The results may prove to be very significant, in that Listeria monocytogenes is particularly dangerous during pregnancy, and in a number of other high risk groups, but is too rare to warrant vaccination or preventative antibiotic therapy. A probiotic taken during pregnancy could well provide protection against Listeria infection in a form which would be acceptable to expectant mothers.

The study was primarily conducted by Sinead Corr as part of her research towards her PhD, but also involved key contributions from other APC scientists Yin Li and Christian Riedel. The research was supervised by APC Principal Investigators Colin Hill, Cormac Gahan and Paul O’Toole from the Department of Microbiology and the School of Pharmacy, UCC.

Catherine Buckley | alfa
Further information:
http://www.ucc.ie
http://apc.ucc.ie

More articles from Health and Medicine:

nachricht Research reveals how diabetes in pregnancy affects baby's heart
13.12.2017 | University of California - Los Angeles Health Sciences

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Long-lived storage of a photonic qubit for worldwide teleportation

12.12.2017 | Physics and Astronomy

Multi-year submarine-canyon study challenges textbook theories about turbidity currents

12.12.2017 | Earth Sciences

Electromagnetic water cloak eliminates drag and wake

12.12.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>