Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cellular Therapy For Pulmonary Tuberculosis

15.06.2007
Specialists of the Central Scientific Research Institute of Tuberculosis (Russian Academy of Medical Sciences) and the Medical Radiological Research Center (Russian Academy of Medical Sciences) have been developing for three years a treatment mode for pulmonary tuberculosis stable forms.

The mode, on top of traditional complex therapy, includes stem cells intravenous injection to the patient, the stem cells being educed from his/her own marrow (mesenchymal stem cells). Clinical observations have proved that in such a way tubercular process can be stopped with practically incurable patients and their state of health can be improved significantly.

The researchers are studing twenty seven patients with stable forms of pulmonary tuberculosis. Pathogenes of these forms are resistant to the majority of antituberculous drugs, including the most active ones. In essence, these patients feel as the people ill with consumption did in the 19th century. Their lungs gradually decay, and the patients pose constant danger to people around as they excrete mycobacteria - tuberculosis pathogenes. Marrow (mesenchymal) stem cells can restore injured pulmonary tissues and increase patients’ resistivity to infection. They possess the property of differentiating into the cells of bone stock, cartilaginous tissue, adipose tissue and some other tissues – including the cells of healthy respiratory epithelium.

To get the stem cells, the patient underwent sternal puncture or iliac bone puncture. The obtained marrow cells were cultivated, (mesenchymal) stem cells being educed and reproduced in the course of cultivation. Transplantation required 150-200 million cells that were injected intravenously to the patient. In the majority of cases, the procedure did not cause complications, and annoying sensations (moderate temperature, ache, a worn out feeling), if any, were over on the next day. The researchers observed 16 patients for 18 to 24 months, and 11 patients – for at least six months. Within the first five months, all patients felt better: dyspnea reduced, asthenia and indisposition were almost over. Twenty four patients gained weight significantly and noted revitalization and burst of energy. Patients’ indicies of blood noticeably improved.

Three to four months after the transplantation, twenty patients ceased to excrete mycobacteria, this meaning that the active process in the lungs had stopped. According to the tomographic imaging research data, chronic cavities in the pulmonary tissue healed up with 11 patients; cavities in both lungs (that had existed for two years) closed with one of the patients. Inflammatory changes in the lungs dissolved with 15 patients, the lysis cavities partly closed or decreased in size.

At present, 9 patients out of 16, who were injected stem cells 18 to 24 month ago, demonstrate steady remission of tubercular process, the inflammatory changes dissolving and destructive changes disappearing in the lungs, the researchers observed considerable positive dynamics with 6 patients. Only in one case out of 16, the mesenchymal stem cells transplantation effect resulted only in a short-term improvement. The patients who underwent cells transplantation several months ago, continue their treatment, the efficiency of which may be judged 12 to 15 months later.

Although mechanisms of stem cells action are not quite clear yet, the results are promising and they allow to count on new prospects in treatment of stable forms of tuberculosis.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>