Mark S. Roberts and colleagues from the University of Pittsburgh used data from a large, multi-centre study to develop their dynamic microsimulation model. This included information on admission date, movement between wards, trips to the intensive care unit, discharge, deaths and disease progression from more than 1,800 patients with pneumonia-related sepsis.
They found that their model closely predicts changing health and the pattern and number of discharges and deaths in patients over a 30-day period. There were 1,776 discharges in the original multi-centre study, and based on the precision of its patient-matching algorithms, the model predicted between 1,779 and 1,804. The model forecast between 62 and 84 of the 85 patients who actually died[MSR1]. The researchers also found the simulation model could predict not only the number but also the pattern of events over time, although the ability to predict when deaths and discharges occur over time varies.
The model has certain advantages over predecessors, which assume a constant rate of disease progression, and often don’t incorporate past clinical history. The result is a more powerful model that can help predict the individual course and outcome of disease. Sepsis affects approximately 750,000 people in the US alone every year, and around a third of these die. With the ability to influence clinical decisions and patient outcomes, this makes the new simulation technique a powerful tool.
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More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
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The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
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