Although there are many causes for this disease, UGR [http://www.ugr.es] scientists focused on smooth muscle cells (SMCs) transformation into dedifferentiated and proliferative cells, able to carry lipids in culture. In this sense, cells from animals fed with control diet represent a difference. Experts carried out an early cell atherosclerosis experimental model with chickens, as these birds develop atherosclerosis very rapidly: a 20-day high cholesterol diet is enough to detect atheromatous plaques in their arteries.
Experts obtained SMCs from arteries before the formation of the plaques. Ten days after the start of the high cholesterol diet – when atheromatous plaques are not still visible using an electron microscopic – aortic SMCs are extracted and in-vitro cultured. Experts cultured SMC-Cs (obtained from animals without a cholesterol dietary supplement) and SMC-Chs (extracted from animals with cholesterol dietary supplement) under the same conditions. After genetic analysis, scientists confirmed that regarding the samples (without cholesterol) modifications took place in birds fed with a high cholesterol diet. Differences show that cholesterol causes changes in messenger RNA synthesis in proteins related to lipid metabolism control, proliferation and apoptosis (programmed cell death) and, therefore, that diet has an influence on gene expression.
Through other studies, these experts discovered that, whilst cholesterol causes changes in gene expression, fish oil reverts such changes. In this case, scientists fed the animals with a high cholesterol diet for ten days, then substituted cholesterol for fish oil (rich in omega-3 and omega-6 polyunsaturated fatty acids) for another ten days.
New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia
New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
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