Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Repeated childhood stroke and venous thrombosis: the risks

11.06.2007
Being over two-years-old, not being administered anti-coagulant drugs, and having a certain genetic mutation all increase the risks of repeated venous thrombosis (VT) in children, conclude authors of an Article published early Online and in the July edition of The Lancet Neurology.

Professor Ulrike Nowak-Göttl, Department of Paediatric Haematology and Oncology, University Hospital of Münster, Germany, and colleagues did a study of 396 children who had suffered a first cerebral venous thrombosis (CVT/stroke), and monitored them for an average of 36 months to determine the risk of a second cerebral or systemic venous thrombosis. The study is the largest and longest follow-up study of children with a first onset of stroke.

They found that 12 of the children died immediately, while 22 had recurrent VT, of which 13 were cerebral. Recurrent VT only occurred in children over two-years-old, and children who did not receive anti-coagulant drugs were 11 times for likely to have recurrent VT. Children suffering from venous occlusion (blocking of the veins to any blood flow) were over four times more likely to have recurrent VT, as were children with a genetic mutation already known to increase risk of VT.

The authors say: “Although cerebral venous thrombosis is associated with substantial mortality and morbidity, its causes in children have not been extensively investigated.”

Children older than two years who had a second VT did so at an average age of 13 years – the authors propose that this is because after the high risk first year of life, the next highest risk period of a child’s life relating to VT is puberty, probably due to hormonal changes and the down-regulation of the fibrinolytic system. This finding is backed by previous studies.

However the authors caution that continued use of anticoagulants in children has to be balanced against the risks of them suffering haemorrhages due to being physically active, and each case has to be considered individually. Where the risk of repeated VT is high, the benefit of anticoagulant therapy could clearly outweigh the risk of possible haemorrhage.

The authors conclude by calling for larger randomised studies into repeated VTs. They say: “Until data from such studies are available, the message of this follow-up study is clearly that administration of secondary anticoagulation prophylaxis should be considered on an individual patient basis in children with newly identified CVT in situations where the risk of VT is high.”

In an accompanying Comment, Dr Meredith Golomb, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, USA, says: “Recurrent venous thromboembolism after cerebral sinovenous thrombosis can be devastating.”

She then asks: “Which patients absolutely need to be on anticoagulation, and which ones can be safely weaned off? How can we tell the parents of an otherwise healthy five-year-old that he can never sled, perform gymnastics, or wrestle with his siblings? What doses of anticoagulation will keep the risk of recurrence and bleeding to a minimum?”

She concludes: “This paper provides some important answers; however, physicians, patients, and the patients’ families have many more questions.”

Tony Kirby | alfa
Further information:
http://www.thelancet.com

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>