Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Preventing flooding of the brain, saving lives

05.06.2007
Researchers have discovered a completely new way to treat stroke and head trauma victims, potentially saving the lives of numerous such patients. The discovery was made by the NordForsk-financed Nordic Centre of Excellence on Water Imbalance Related Disorders (WIRED).

After head trauma or after stroke, brain swelling - caused by an influx of water into the brain - is one of the factors most likely to cause death, taking a great toll on society in terms of human suffering and economical costs.

The development of efficient therapies for this condition has been hampered by a lack of information regarding the route of water flow into the brain. But new data from the NordForsk-financed WIRED have singled out the water channel called aquaporin-4 as the carrier of water from the blood and into the brain.

This has opened up new possibilities for treating stroke and head trauma victims. By simply closing these water channels in the brain, the swelling can be significantly reduced. Reduced brain swelling drastically improves patients’ chances of avoiding long-term damage and increases survival prospects. Stroke affects almost 100 000 patients each year in the Nordic countries. Improved ways to treat these patients will considerably reduce the human suffering and economic costs associated with this condition.

The Centre is now actively searching for drugs that can be used to close the water channels in the brain, and some very promising candidates have been identified.

However, knowledge of water transport and water channels in the human body is not only relevant to stroke patients. Such knowledge could also help improve the treatment of patients with kidney disease and might in the future lead to new therapies for patients with migraine. More than 10% of the Nordic population is affected by migraine, and researchers believe that the condition is associated with a perturbation of water transport.

The impressive research results achieved by WIRED were made possible by the unique environment that the Nordic countries offer for research in the field of molecular medicines. Assets include extensive and reliable patient and epidemiological registries, biobanks, uniform high level health care systems, as well as a strong tradition in genetic and biomedical research.

Kristin Oxley | alfa
Further information:
http://www.nordforsk.org

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Organ-on-a-chip mimics heart's biomechanical properties

23.02.2017 | Health and Medicine

Light-driven reaction converts carbon dioxide into fuel

23.02.2017 | Life Sciences

Oil and gas wastewater spills alter microbes in West Virginia waters

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>