After head trauma or after stroke, brain swelling - caused by an influx of water into the brain - is one of the factors most likely to cause death, taking a great toll on society in terms of human suffering and economical costs.
The development of efficient therapies for this condition has been hampered by a lack of information regarding the route of water flow into the brain. But new data from the NordForsk-financed WIRED have singled out the water channel called aquaporin-4 as the carrier of water from the blood and into the brain.
This has opened up new possibilities for treating stroke and head trauma victims. By simply closing these water channels in the brain, the swelling can be significantly reduced. Reduced brain swelling drastically improves patients’ chances of avoiding long-term damage and increases survival prospects. Stroke affects almost 100 000 patients each year in the Nordic countries. Improved ways to treat these patients will considerably reduce the human suffering and economic costs associated with this condition.
The Centre is now actively searching for drugs that can be used to close the water channels in the brain, and some very promising candidates have been identified.
However, knowledge of water transport and water channels in the human body is not only relevant to stroke patients. Such knowledge could also help improve the treatment of patients with kidney disease and might in the future lead to new therapies for patients with migraine. More than 10% of the Nordic population is affected by migraine, and researchers believe that the condition is associated with a perturbation of water transport.
The impressive research results achieved by WIRED were made possible by the unique environment that the Nordic countries offer for research in the field of molecular medicines. Assets include extensive and reliable patient and epidemiological registries, biobanks, uniform high level health care systems, as well as a strong tradition in genetic and biomedical research.
Kristin Oxley | alfa
GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University
Scientists re-create brain neurons to study obesity and personalize treatment
20.04.2018 | Cedars-Sinai Medical Center
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
23.04.2018 | Physics and Astronomy
23.04.2018 | Physics and Astronomy
23.04.2018 | Trade Fair News