Designed for health professionals, the guidelines propose detailed protocols for challenge tests. The paper is endorsed by the European Academy of Allergology and Clinical Immunology (EAACI) and GA²LEN partners.
Most people tolerate aspirin very well. For others, however, aspirin and other non-steroidal anti-inflammatory drugs trigger allergy-like asthma, sinusitis or urticaria. Reactions can be as violent and life-threatening as asthma attacks and anaphylaxis.
Hypersensitivity to aspirin has been observed since early 20th century. Today, it is one of the most common adverse reactions to a medicinal product. It is however largely under-diagnosed.
A challenge test is the only way to identify aspirin sensitivity. The patient is administered small doses of aspirin that are regularly increased, under direct supervision of a physician in a clinical environment. Hypersensitivity to aspirin is recognised when the patient’s lung function is depressed by more than 20%.
“We hope this position paper will enable physicians to proceed with diagnosis,” concludes Prof. Szczeklik, the main author of the paper. A long list of non-steroidal, anti-inflammatory drugs for common indications, such as headache, is contraindicated to hypersensitive patients. “A proper diagnosis will have a real benefit for them as they will be directed by their doctors to alternative medication that are completely safe to take, without any side-effect.”
While at least 0.5% of the general population is known to suffer from aspirin sensitivity, asthmatics are especially likely to be affected. According to a recent study, about 20% of asthmatic adults are hypersensitive to aspirin.
Noélie Auvergne | alfa
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology