Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Transplanting human gut bugs into mice helps understanding of metabolic system

22.05.2007
Bugs found in the guts of humans, which play an important part in people’s metabolic makeup, have been transplanted into mice to further understanding of the human and animal metabolic system, reveals a new study in the journal Molecular Systems Biology.

Bugs in the gut are known as gut microbes and they live symbiotically in human and animal bodies. The new study involved understanding the major role that gut microbes have in determining how the body absorbs fat and digests fibre, and their effects on metabolic pathways in the body.

The researchers, from Imperial College London and Nestlé Research Center, Lausanne, Switzerland, found that microbes affect the way fats are absorbed and metabolised, by affecting bile acids. Bile acids are made by the liver to allow emulsification of fats in the upper gut. The researchers found that gut microbes can change how effective this emulsification process is because they metabolise bile acids.

The bile acids are also hormonal regulators which change the way fat is processed in the liver, so changes made by gut microbes to bile acid metabolism can affect this internal process.

The scientists also explored how microbes break down fibre in the lower gut. Certain microbes allow dietary fibre to be digested and the more effective these microbes are, the more calories are absorbed from the diet.

Different people have different types of gut microbes living inside them and abnormalities in some types have recently been linked to diseases such as diabetes and obesity. The scientists believe that transplanting the bugs found in humans into mice will enable better understanding of gut microbes’ effects, good and bad, and help them to develop better treatments (including probiotics and functional foods) for a wide range of conditions.

Professor Jeremy Nicholson, one of the lead authors of the paper from the Department of Biomolecular Medicine at Imperial College London, said: “Humans carry around 1.5kg of bacteria inside of us – that’s the same sort of weight as your liver, so they have a big metabolic effect on our bodies. By transplanting human gut microbes into mice, scientists from Nestlé Research Center, Lausanne were able to make them partially human from a metabolic point of view, because we made their biochemistry more like ours. This makes studies on mice much more relevant to human problems.

“We found that the humanised mice had very different metabolic profiles to normal mice with respect to the metabolism of fats and in future we might be able to modify their metabolism using probiotics, like those found in some natural yoghurts. This gives us a new way of studying the beneficial effects of probiotics and functional foods and understanding what they do to our “friendly” bacteria. Our new approach allows us to explore which bugs are doing what in metabolic terms, to identify which bugs which might be causing chronic health problems, and investigate what effects different foods and probiotics can have on improving overall health,” he added.

Laura Gallagher | alfa
Further information:
http://www.imperial.ac.uk

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

On the way to developing a new active ingredient against chronic infections

21.08.2017 | Life Sciences

Smart Computers

21.08.2017 | Information Technology

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>