For years, physicians have assumed that alcohol abuse leads to cardiovascular diseases. However, other data has also appeared recently, in which moderate doses of alcohol resist initiation of these diseases, particularly coronary heart disease. On the one hand, ethanol increases arterial pressure, concentrating fatty acids and urea in the blood. On the other hand, ethanol decreases cholesterol and encourages blood protein coagulation and thrombi formation.
The action of alcohol ingested largely depends on its concentration in the blood. About 90 percent of ethanol is decomposed in the liver, with several enzymes participating in the process: alcohol dehydrogenases, acetaldehyde dehydrogenases, 2'1-class '450 cytochromes and some others. Diversity in the sequences of these enzymes’ genes, or their genetic polymorphism impacts the ethanol disintegration rate and the diseases connected with its abuse, as well as predisposition to cardiovascular diseases. For example, certain mutations in the alcohol dehydrogenase genes with Japanese men allow to oxidize ethanol 100 to 200 times quicker. Therefore, polymorphism of the genes participating in ethanol disintegration should tell upon the cardiovascular system state.
The Tomsk geneticists examined a group of patients with a diagnosis of ischemic cardiac disease and coronary atherosclerosis. The reference group consisted of practically healthy inhabitants of Tomsk. All participants to the experiment were examined from the point of view of cardiovascular system state and polymorphism of several genes: two genes of alcohol dehydrogenase (ADH1B and ADH7) and 'YP2'1 cytochrome gene.
The researchers found mutant variants of these genes, which influence blood pressure, fatty acids and lipoproteins concentration. The same genes determine the ethanol disintegration rate. The researchers assume that the genes’ influence on lipidic exchange and blood pressure is unconnected with the ethanol disintegration function. It is probable that the enzymes, whose operation is determined by these genes, perform several functions. However, these genes can probably be used as markers of alcoholic dependence.
Nadezda Markina | alfa
Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Health and Medicine
23.01.2017 | Physics and Astronomy
23.01.2017 | Process Engineering