Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

How insulin-producing cells develop: new finding could help fight against diabetes

21.05.2007
A key aspect of how embryos create the cells which secrete insulin is revealed in a new study published tomorrow (18 May) in the Journal of Biological Chemistry. The researchers hope that their findings will enable the development of new therapies for diabetes, a condition caused by insufficient levels of insulin.

The research reveals that glucose plays a key role in enabling healthy beta cells, which secrete insulin, to develop in the pancreas of an embryo. Glucose prompts a gene called Neurogenin3 to switch on another gene, known as NeuroD, which is crucial for the normal development of beta cells. If glucose levels are low this gene is not switched on.

Insulin is the principal hormone that regulates the uptake of glucose and if the beta cells are unable to produce sufficient insulin, this can cause diabetes.

The scientists, from Imperial College London and an INSERM Unit at Necker Hospital, Paris, hope that understanding how to switch on the gene that produces beta cells could eventually enable researchers to create these cells from stem cells. They could then transplant beta cells into patients with type 1 diabetes. In this type of diabetes the immune system attacks patients' beta cells and at the moment few patients with the condition are able to have beta cell transplants, because the cells have to be taken from deceased donors.

The researchers also hope that scientists will be able to develop drug therapies that enhance the action of glucose and hence encourage the growth of healthy beta cells.

Professor Guy Rutter, from the Division of Medicine at Imperial College and one of the authors of the paper, said: "We hope that by demonstrating that an 'extrinsic' factor like glucose can regulate the way in which insulin secreting cells develop we may eventually be able to reverse defects in the growth of these cells in patients with diabetes. Research like ours is opening up whole new sets of targets for drug treatments."

The researchers reached their conclusions after conducting research on tissues cultured from the primordial pancreas of very young rat embryos. Using an in vitro system, rather than looking at cells in vivo, enables researchers to gain a greater understanding of when and how different genes are being switched on.

Laura Gallagher | alfa
Further information:
http://www.imperial.ac.uk

More articles from Health and Medicine:

nachricht Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign

nachricht Rabies viruses reveal wiring in transparent brains
19.01.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>