Professor Olof Nyrén and Gustaf Edgren, Karolinska Institutet, Stockholm, Sweden together with Professor Mads Melbye and Dr Henrik Hjalgrim from Statens Serum Institut, Copenhagen, Denmark organised a binational project to study the cancer incidence among patients who received blood from donors deemed to have a subclinical cancer at the time of donation.
Using data from all computerised blood bank registers in Sweden and Denmark that were gathered between 1968 and 2002, the researchers identified 1.13 million blood donors and 1.31 million transfusion recipients. Out of the more than 350,000 recipients eligible for the analysis, just over 12,000 (3%) were exposed to blood products from precancerous donors. The recipients were followed for as long as 34 years.
The authors say: “Continuous attention to transfusion safety has reduced the risk of transfusion-transmitted disease to a current record low. However, although most infectious complications have been relatively easy to identify, possible transmission of chronic diseases with unknown causes and long induction or latency periods has been far more difficult to address.”
They conclude: “Our data provide no evidence that blood transfusions from precancerous blood donors are associated with increased risk of cancer among recipients compared with transfusions from non-cancerous donors.”
In an accompanying Comment, Dr Garth Utter, Department of Surgery, University of California, Davis, Sacramento, California, USA, says: “Blood is an immensely complex and biologically active substance. Although the potential for standard allogeneic blood transfusion to save lives is incontrovertible, our understanding of the full consequences of transfusion is rudimentary.”
He adds: “With their thoughtful analysis of a large and relatively complete dataset, Edgren and colleagues have taken an important stride forward in evaluating one of these potential long-term risks of blood transfusion.”
Tony Kirby | alfa
Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University
The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
05.12.2016 | Power and Electrical Engineering
05.12.2016 | Information Technology
05.12.2016 | Earth Sciences