Professor Olof Nyrén and Gustaf Edgren, Karolinska Institutet, Stockholm, Sweden together with Professor Mads Melbye and Dr Henrik Hjalgrim from Statens Serum Institut, Copenhagen, Denmark organised a binational project to study the cancer incidence among patients who received blood from donors deemed to have a subclinical cancer at the time of donation.
Using data from all computerised blood bank registers in Sweden and Denmark that were gathered between 1968 and 2002, the researchers identified 1.13 million blood donors and 1.31 million transfusion recipients. Out of the more than 350,000 recipients eligible for the analysis, just over 12,000 (3%) were exposed to blood products from precancerous donors. The recipients were followed for as long as 34 years.
The authors say: “Continuous attention to transfusion safety has reduced the risk of transfusion-transmitted disease to a current record low. However, although most infectious complications have been relatively easy to identify, possible transmission of chronic diseases with unknown causes and long induction or latency periods has been far more difficult to address.”
They conclude: “Our data provide no evidence that blood transfusions from precancerous blood donors are associated with increased risk of cancer among recipients compared with transfusions from non-cancerous donors.”
In an accompanying Comment, Dr Garth Utter, Department of Surgery, University of California, Davis, Sacramento, California, USA, says: “Blood is an immensely complex and biologically active substance. Although the potential for standard allogeneic blood transfusion to save lives is incontrovertible, our understanding of the full consequences of transfusion is rudimentary.”
He adds: “With their thoughtful analysis of a large and relatively complete dataset, Edgren and colleagues have taken an important stride forward in evaluating one of these potential long-term risks of blood transfusion.”
Tony Kirby | alfa
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.
The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
29.05.2017 | Earth Sciences
29.05.2017 | Life Sciences
29.05.2017 | Physics and Astronomy