Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lymphocyte count found to be a predictor of survival for young patients with leukemia

09.05.2007
One simple blood test could predict relapse or survival for children and young adults with acute leukemias, researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center reported at the American Society of Pediatric Hematology Oncology's annual meeting Saturday, May 5.

A review of young leukemia patients over the past decade has shown that the absolute lymphocyte count (ALC), a measure of normal immune cells found on every complete blood count report, is a powerful predictor of survival for young patients with leukemia.

According to the American Cancer Society, the average rate of survival for pediatric patients with acute myelogenous leukemia (AML) is close to 50 percent. However, researchers have found that using the ALC count on day 15 after initial chemotherapy treatment can significantly predict which patients are likely to relapse and those who will not.

This prediction may help physicians decide how aggressively to treat a leukemia patient. In addition, it may direct researchers in developing therapies to increase a patient's ability to battle the leukemia cells.

"Possibly by tweaking the immune system through chemotherapy, immune modulators or oral supplements, we could help a patient's body better fight leukemia," says Guillermo De Angulo, M.D., researcher and fellow at the Children's Cancer Hospital at M. D. Anderson. "This ALC test could also help us identify patients who would benefit from less chemotherapy."

The report studied 171 patients with either AML or acute lymphocytic leukemia (ALL), 21 years or younger, who had begun treatment at M. D. Anderson between 1995 and 2005. The statistics showed significant differences in survival rates in multiple analyses.

The results from the study showed that AML patients who had a low lymphocyte count on day 15 of treatment had a five-year overall survival chance of only 28 percent. However, patients with higher lymphocytes on day 15 had a much better overall survival rate of 85 percent.

For patients with ALL, the most common form of childhood leukemia, researchers found that those children and young adults with a high ALC count on day 15 had an 87 percent six-year overall survival rate while those with a low lymphocyte count had a 55 percent overall survival rate.

Researchers at the Children's Cancer Hospital plan to continue their study by following newly diagnosed patients and have begun a new study that analyzes the subsets of lymphocytes to see which ones have the most impact on prognosis. They hope their findings will be used to help physicians worldwide make decisions on how aggressively to treat their patients.

"Many developing countries lack the latest technologies and treatment options that we have here in the United States," says senior author Patrick Zweidler-McKay, M.D., Ph.D., assistant professor of pediatrics. "A complete blood count test is a universal, inexpensive test. There is the potential for physicians worldwide to look at the ALC count to help determine whether the patient needs additional treatment options that aren't available in every center."

Sara Farris | EurekAlert!
Further information:
http://www.mdanderson.org

More articles from Health and Medicine:

nachricht TSRI researchers develop new method to 'fingerprint' HIV
29.03.2017 | Scripps Research Institute

nachricht Periodic ventilation keeps more pollen out than tilted-open windows
29.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Researchers shoot for success with simulations of laser pulse-material interactions

29.03.2017 | Materials Sciences

Igniting a solar flare in the corona with lower-atmosphere kindling

29.03.2017 | Physics and Astronomy

As sea level rises, much of Honolulu and Waikiki vulnerable to groundwater inundation

29.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>