Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Side-effect of radiation treatment offers new hope for preventing transplant rejection

08.05.2007
A radiation treatment currently used to prepare patients for a bone marrow transplant causes changes in the immune system which encourage the body to accept donated bone marrow rather than reject it, according to new research.

The scientists, from Imperial College London, hope that their findings will help the development of new therapies to stop the immune system from rejecting these and other kinds of transplants. The research, which was funded by Cancer Research UK, is published today in the journal PNAS.

Bone marrow transplants are used to enable patients to produce healthy blood cells. However, the host immune system can sometimes attack the donor immune cells from the transplanted bone marrow. Radiation treatment is given before the transplant to create space in the host bone marrow for donor immune cells to inhabit and, in the case of patients with leukaemia, to kill the leukaemia cells.

The new research, which used mouse models, shows that during this process, many of the T cells which mediate the immune response are killed. However, regulatory T cells are able to survive and proliferate, suggesting that they have more resistance to irradiation. Regulatory T cells stop other T cells from attacking the transplanted cells, and so encourage the immune system to accept the transplant.

At present this effect is not sufficiently strong to prevent rejection of bone marrow transplants, but the scientists hope the findings will enable them to develop new ways of curbing rejection.

Professor Francesco Dazzi, from the Kennedy Institute of Rheumatology at Imperial College London, who led the study, said: “Perfect tissue matching is rarely possible and this means the body's immune system recognises transplanted bone marrow as foreign and attacks it. Our new research shows that the regulatory cells which proliferate are able to recognise the foreign tissue and yet stop other immune cells from attacking it. Having uncovered a fundamental process the body uses to control the response to foreign tissue, we can now develop strategies to exploit this effect and control rejection of bone marrow and potentially other organ transplants.”

Laura Gallagher | alfa
Further information:
http://www.imperial.ac.uk

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>