Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Side-effect of radiation treatment offers new hope for preventing transplant rejection

08.05.2007
A radiation treatment currently used to prepare patients for a bone marrow transplant causes changes in the immune system which encourage the body to accept donated bone marrow rather than reject it, according to new research.

The scientists, from Imperial College London, hope that their findings will help the development of new therapies to stop the immune system from rejecting these and other kinds of transplants. The research, which was funded by Cancer Research UK, is published today in the journal PNAS.

Bone marrow transplants are used to enable patients to produce healthy blood cells. However, the host immune system can sometimes attack the donor immune cells from the transplanted bone marrow. Radiation treatment is given before the transplant to create space in the host bone marrow for donor immune cells to inhabit and, in the case of patients with leukaemia, to kill the leukaemia cells.

The new research, which used mouse models, shows that during this process, many of the T cells which mediate the immune response are killed. However, regulatory T cells are able to survive and proliferate, suggesting that they have more resistance to irradiation. Regulatory T cells stop other T cells from attacking the transplanted cells, and so encourage the immune system to accept the transplant.

At present this effect is not sufficiently strong to prevent rejection of bone marrow transplants, but the scientists hope the findings will enable them to develop new ways of curbing rejection.

Professor Francesco Dazzi, from the Kennedy Institute of Rheumatology at Imperial College London, who led the study, said: “Perfect tissue matching is rarely possible and this means the body's immune system recognises transplanted bone marrow as foreign and attacks it. Our new research shows that the regulatory cells which proliferate are able to recognise the foreign tissue and yet stop other immune cells from attacking it. Having uncovered a fundamental process the body uses to control the response to foreign tissue, we can now develop strategies to exploit this effect and control rejection of bone marrow and potentially other organ transplants.”

Laura Gallagher | alfa
Further information:
http://www.imperial.ac.uk

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>