Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Potential new target for cancer treatment

08.05.2007
A discovery made by a research team at the Sahlgrenska Academy in Göteborg may lead to new treatments for lung cancer and blood cancer, among others. By stopping the production of a particular enzyme in mice, they reduced the development of tumors, and the mice survived considerably longer.

In many forms of cancer the growth of tumors and their capacity to spread is stimulated by a number of CAAX proteins. This has led to intensive research into how to block the activity of these proteins.

"The enzyme we are studying develops CAAX proteins so that they will take on the properties that stimulate cancer growth. By blocking this enzyme, we may be able to reduce the modification of CAAX proteins in a new cancer model in mice," says Associate Professor Martin Bergö, who directs this research at the Wallenberg Laboratory, Sahlgrenska Academy.

The research team uses a genetically modified mouse that produces a muted and constantly active CAAX protein. This is a new model for an extremely aggressive lung cancer and a mild form of blood cancer. In these mice, the production of an enzyme called GGTas1 can also be stopped.

"When we inhibited the production of the enzyme, tumor development decreased dramatically. The mice survived considerably longer, and all signs of blood cancer disappeared. A drug that blocks this enzyme can be an effective future cancer treatment," says Martin Bergö.

The findings strongly indicate that the enzyme GGTas1 is a promising target for cancer treatment. At the cell level, inhibition of the enzyme resulted in blocked cell growth and decreased cell mobility.

"Another interesting discovery in this study was that many types of cells appear to be able to survive without the enzyme. This is important from the point of view of toxicology, since you want a drug to attack only the cancer cells and not normal cells and tissues," says Martin Bergö.

The research team is now pursuing the question of whether GGTas1 can also be an effective target for treating other types of cancer. They will also be ensuring that inhibiting this enzyme does not damage other cell types and tissues.

For more information, please contact: Associate Professor Martin Bergö, phone: +46(0)31-342 78 58; e-mail: martin.bergo@wlab.gu.se Journal: Journal of Clinical Investigation Title of article: GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer Authors: Anna-Karin M. Sjögren, Karin M.E. Andersson, Meng Liu, Briony A. Cutts, Christin Karlsson, Annika M. Wahlström, Martin Dalin, Carolyn Weinbaum, Patrick J. Casey, Andrej Tarkowski, Birgitta Swolin, Stephen G. Young, Martin O. Bergö

Elin Lindström Claessen | idw
Further information:
http://www.vr.se

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>