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When Depression Is Really Over: New Criteria For Remission

02.05.2007
Depression is diffucult to treat and overcome completely. When can you say it is over? Giovanni Fava, Chiara Ruini and Carlotta Belaise of the University of Bologna have examined the literature on recovery and have proposed new criteria for remission.

The aims of this review were to survey the available literature on residual symptoms of depression, to introduce new targets for therapy and to outline a more stringent definition of recovery.

Studies were identified by using MEDLINE (English language articles published from 1967 to June 2006; keywords: recovery, remission, residual symptoms, sequential treatment, drugs and psychotherapy, related to depressive disorder and depression) and a manual search of the literature and Index Medicus for the years 1960–2006.

Most patients report residual symptoms despite apparently successful treatment. Residual symptoms upon remission have a strong prognostic value. There appears to be a relationship between residual and prodromal symptomatology. The concept of recovery should involve psychological well-being.

Appraisal of subclinical symptomatology in depression has important implications for pathophysiological models of disease and relapse prevention. New therapeutic strategies for improving the level of remission, such as treatment on residual symptoms that progress to become prodromes of relapse, may yield more lasting benefits.

Giovanni Andrea Fava | alfa
Further information:
http://www.unibo.it

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