New Treatment For Fungi Which Cause Thrush And Sepsis
A new treatment for Candida species of fungi which can cause thrush and sepsis (a life-threatening infection leading to fever, hypotension, and shock) has proven equally effective as the existing treatment in a drug trial.
But the new drug has fewer side effects, claims an article published Online and in an upcoming edition of The Lancet.
Infections caused by Candida fungi have become increasingly prevalent in recent years, and problems associated with long established treatments are well known.
Researchers led by Oliver Cornely, of The University Hospital of Cologne, Germany, tested the effectiveness of two well known treatments, liposomal amphotericin B and micafungin, against the common infections candidaemia and invasive candidosis.
A total of 531 patients with these infections were split into two groups and given either micafungin 100mg per day or liposomal amphotericin B 3mg per kg body weight daily. The success rate of both drugs was almost exactly the same – 89.6% for micofungin versus 89.6% for liposomal amphotericin B.
The effectiveness of either treatment was independent of primary site of infection and the patient’s immune status, and whether or not a catheter had been fitted during treatment.
But micafungin produced fewer treatment related side effects than liposomal amphotericin B. Increased problems with kidney function, as well as higher occurrence of problems during drug administration, were observed in the patients receiving liposomal amphotericin B.
The authors conclude: “Our results establish micafungin as a treatment option for first-line therapy of candidaemia and invasive candidosis.”
They add: “Micafungin also has broad-spectrum activity against Aspergillosis spp, thus to assess its efficacy in the treatment of invasive aspergillosis will be an important future goal.”
Tony Kirby | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...