But the new drug has fewer side effects, claims an article published Online and in an upcoming edition of The Lancet.
Infections caused by Candida fungi have become increasingly prevalent in recent years, and problems associated with long established treatments are well known.
Researchers led by Oliver Cornely, of The University Hospital of Cologne, Germany, tested the effectiveness of two well known treatments, liposomal amphotericin B and micafungin, against the common infections candidaemia and invasive candidosis.
A total of 531 patients with these infections were split into two groups and given either micafungin 100mg per day or liposomal amphotericin B 3mg per kg body weight daily. The success rate of both drugs was almost exactly the same – 89.6% for micofungin versus 89.6% for liposomal amphotericin B.
The effectiveness of either treatment was independent of primary site of infection and the patient’s immune status, and whether or not a catheter had been fitted during treatment.
But micafungin produced fewer treatment related side effects than liposomal amphotericin B. Increased problems with kidney function, as well as higher occurrence of problems during drug administration, were observed in the patients receiving liposomal amphotericin B.
The authors conclude: “Our results establish micafungin as a treatment option for first-line therapy of candidaemia and invasive candidosis.”
They add: “Micafungin also has broad-spectrum activity against Aspergillosis spp, thus to assess its efficacy in the treatment of invasive aspergillosis will be an important future goal.”
Tony Kirby | alfa
Scientists develop tiny tooth-mounted sensors that can track what you eat
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An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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