The research could mean people who might react badly to radiotherapy could be warned in advance or alternative treatments be sought. There is no test at present for an abnormal reaction to radiotherapy. No-one in the past has proposed such a test.
The team who carried out the study included Drs Paul Symonds, Mark Plumb, Irene Peat and George Giotopoulos of the Department of Cancer Studies and Molecular Medicine and the Department of Genetics at the University of Leicester. Their results are published in the British Journal of Cancer.
Dr Symonds said: “Radiotherapy is a very important treatment for breast cancer. A small number of people can develop severe side effects.”
“During treatment patients can get redness of the skin which may peel off. Later the breast may shrink (atrophy) and the tissues under the skin may become hard and thickened (fibrosis). Red widened blood vessels can appear in the skin (telangiectasia).”
After examining patients at the Glenfield Hospital, Leicester Royal Infirmary and the City Hospital Nottingham, the team at the University of Leicester, funded in part by the Hope Foundation for Cancer Research, has found 2 separate genes strongly associated with either thickening of tissue or red widened blood vessels.
“About 8% of women carry the fibrosis gene and have 15 times the risk of developing thickening of the tissues which is often associated with lifelong chronic pain.
“The genes we have identified at present have a predictive value of 50-60% for the development of marked fibrosis with breast pain. If we could identify the acute genes that lead to marked redness and peeling of the skin, this could increase the predictive value of the test to almost 100%.”
Dr Symonds said further work needs to be done as the researchers have not found the genes responsible for redness and peeling of the skin during treatment.
“In the future it may be possible to identify people who are going to react badly to radiotherapy. Such patients should only receive radiation treatment if there is no alternative and be warned of an increased risk of fibrosis,” he said.
Alex Jelley | alfa
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
27.04.2017 | Life Sciences
27.04.2017 | Physics and Astronomy
27.04.2017 | Earth Sciences