Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Promising Treatment for Post Traumatic Stress Disorder (PTSD) Sleep Disturbances

18.04.2007
For sufferers of Post Traumatic Stress Disorder (PTSD), sleep disturbances are among the most treatment-resistant symptoms and can lead to drug and alcohol abuse and even suicide. Previously, there has been little success in treating these sleep disorders with psychopharmacologic approaches.

In a study in the April 15th issue of Biological Psychiatry, researchers have found that an inexpensive, widely available drug was successful in reducing symptoms in chronic PTSD patients.

In a placebo-controlled, blinded study of 40 veterans of the Vietnam War (32 subjects), World War II (2), the Korean War (3), the Panama invasion (1) and the first Gulf War (2), prazosin was significantly more effective than placebo in reducing trauma nightmares, improving sleep quality and improving the general clinical condition of the treated patients.

Subjects were assessed using three primary outcome measures, the CAPS “recurrent distressing dreams” item, the Pittsburgh Sleep Quality Index (PSQI) and the Clinical Global Impression of Change (CGIC). The CAPS “recurrent distressing dreams” item measures frequency and intensity of trauma-related distressing dreams. The PSQI is a self-report scale assessing sleep quality and sleep disturbance. The CGIC is an investigator rated assessment of change in global clinical status, which was defined in this study as sense of well-being and ability to function in daily activities.

Improvements in all three measures were observed, with 71% of the subjects receiving prazosin having “moderately or markedly improved” CGIC scores at the end of the study, compared to 12% of those receiving placebo.

Writing in the article, Murray A. Raskind, MD, states, “These results support the therapeutic use of prazosin for PTSD in combat veterans who present with trauma nightmares and sleep disturbance. Clinical experience suggests that prazosin also is beneficial for PTSD trauma nightmares and sleep disturbance in young civilian trauma victims, young veterans of the current conflict in Iraq and Afghanistan and in elderly World War II and Korean War combat veterans and Holocaust survivors.”

The article is “A Parallel Group Placebo Controlled Study of Prazosin for Trauma Nightmares and Sleep Disturbance in Combat Veterans with Posttraumatic Stress Disorder” by Murray A. Raskind, Elaine R. Peskind, David J. Hoff, Kimberly L. Hart, Hollie A. Holmes, Daniel Warren, Jane Shofer, James O’Connell, Fletcher Taylor, Christopher Gross, Kirsten Rohde, and Miles E. McFall. The authors are all from the Veterans Affairs Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC); Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, Washington. The article appears in Biological Psychiatry, Volume 61, Issue 8 (April 15, 2007), published by Elsevier.

Jayne Dawkins | alfa
Further information:
http://www.elsevier.com

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>