Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Preoperative chemotherapy is a safe option for women with early stage operable breast cancer

Latest Findings from The Cochrane Library

Chemotherapy is frequently given to women with breast cancer after surgery to remove the main bulk of the tumour. A new Cochrane Systematic Review of existing data shows, however, that using chemotherapy to reduce the size of tumours before surgery does not compromise survival rates and enables women to retain better self-image and overall health because of the reduced impact of the surgery.

Cancer therapy depends on killing or removing cancerous cells as quickly as possible. Surgery involves either the removal of all breast tissue (mastectomy) or removal of just the tumour and immediate tissue (lumpectomy). Relative to mastectomy, lumpectomy reduces the scale of the surgery required, and improves self-image. Lumpectomy also has equal overall survival to mastectomy, however, this surgical option also results in a greater chance of the cancer reoccurring.

The longer the cancer cells are in the body, the more chance that a secondary cancer will develop. A logical approach, therefore, is to surgically remove as much of the tumour as possible as quickly as possible, and then use chemotherapy to kill any remaining cancer cells. Although this management has improved survival for women significantly over the last twenty years, this approach also requires extensive surgery which can lead to added physical and psychological difficulties for many women.

A team of Cochrane Researchers therefore set out to assess the safety of giving chemotherapy before surgery. This approach reduces the amount of tissue that has to be removed, but carries the risk that tumour cells that are not killed by the chemotherapy may spread before the tumour can be surgically removed. The review identified 14 randomised controlled trials involving a total of 5,500 women.

Compared to postoperative chemotherapy, preoperative chemotherapy reduced the number of mastectomies performed thereby enabling women to undergo less extensive surgery. Women receiving treatment before surgery were also less likely to suffer from serious infections. There were, however, no differences between the two methods in the length of time that women were disease-free after treatment.

“Our review showed a decreased number of adverse effects associated with preoperative chemotherapy,” says lead researcher Mr Sven Mieog, who works at Leiden University Medical Center, in the Netherlands.

“It is important, however, to discuss with the patient the balance of breast conservative surgery between better quality of life and the slight increase in risk of local re-growth of the tumour, with the consequent need for further treatment,” he adds.

Jennifer Beal | alfa
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>