Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Difficult to give prognosis for early prostate cancer

A common prognostic method for men diagnosed with localised prostate cancer turns out to be less effective than was previously thought, according to a new study by scientists at Karolinska Institutet.

The research team measured concentrations of PSA (Prostate-specific Antigen) in the blood of a group of cancer patients and then monitored the development of the disease.

The present study was conducted as part of the Scandinavian Prostate Cancer Group collaboration (project SPCG-4). The conclusion drawn by the research team is that the PSA value for the period after the diagnosis is insufficient as a method of distinguishing with any certainty the men who will develop a fatal cancer from those with a slower tumour growth. In general, men with localised prostate cancer have a good chance of surviving the disease, even without treatment. Yet many still undergo major surgery or radiotherapy, which carries the risk of impaired sexual function and urine incontinence.

"We have to find better methods of separating the patients who will develop malignant prostate cancer from those with a more benign disease," says PhD Katja Fall at Karolinska Institutet, one of the scientists behind the study. "This is important, not only to avoid unnecessary suffering, but also to make sure that hospital resources are directed towards the patients who need it most."

Previous research has shown that there is a link between how quickly the tumour will grow and the speed with which blood levels of PSA increase in the first stages of the cancer. To examine how accurately PSA development can predict the patient's prognosis, Dr Fall and her colleagues in the Scandinavian Prostate Cancer Group monitored 267 men from Sweden, Finland and Iceland diagnosed with prostate cancer between 1989 and 1999.

The PSA values measured in the first two years after diagnosis were used to describe the appearance of the early PSA curve for each patient. On follow-up at the end of 2003, 34 patients had died of prostate cancer and 18 had developed metastases but were still alive. Despite the fact that the PSA reading and the speed with which it increased during these first two years correlated with the development of aggressive prostate cancer, neither of these values was able to screen out with any certainty which patients would have needed intensive treatment from amongst those who would have managed just as well without.

"Prostate-Specific Antigen Levels as a Predictor of Lethal Prostate Cancer"
Katja Fall, Hans Garmo, Ove Andrén, Anna Bill Axelson, Jan Adolfsson, Hans-Olov Adami, Jan-Erik Johansson, Lars Holmberg

Journal of the National Cancer Institute, Vol. 99, nr 7. 4 April 2007

For further information: Dr Katja Fall Tel: +46 (0)8-5248 6109 or +46 (0)709-221974 (mobile) Email: Press Officer Sabina Bossi Tel: +46 (0)8-524 860 66 Email:

Katarina Sternudd | idw
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>