The research team measured concentrations of PSA (Prostate-specific Antigen) in the blood of a group of cancer patients and then monitored the development of the disease.
The present study was conducted as part of the Scandinavian Prostate Cancer Group collaboration (project SPCG-4). The conclusion drawn by the research team is that the PSA value for the period after the diagnosis is insufficient as a method of distinguishing with any certainty the men who will develop a fatal cancer from those with a slower tumour growth. In general, men with localised prostate cancer have a good chance of surviving the disease, even without treatment. Yet many still undergo major surgery or radiotherapy, which carries the risk of impaired sexual function and urine incontinence.
"We have to find better methods of separating the patients who will develop malignant prostate cancer from those with a more benign disease," says PhD Katja Fall at Karolinska Institutet, one of the scientists behind the study. "This is important, not only to avoid unnecessary suffering, but also to make sure that hospital resources are directed towards the patients who need it most."
Previous research has shown that there is a link between how quickly the tumour will grow and the speed with which blood levels of PSA increase in the first stages of the cancer. To examine how accurately PSA development can predict the patient's prognosis, Dr Fall and her colleagues in the Scandinavian Prostate Cancer Group monitored 267 men from Sweden, Finland and Iceland diagnosed with prostate cancer between 1989 and 1999.
The PSA values measured in the first two years after diagnosis were used to describe the appearance of the early PSA curve for each patient. On follow-up at the end of 2003, 34 patients had died of prostate cancer and 18 had developed metastases but were still alive. Despite the fact that the PSA reading and the speed with which it increased during these first two years correlated with the development of aggressive prostate cancer, neither of these values was able to screen out with any certainty which patients would have needed intensive treatment from amongst those who would have managed just as well without.Publication:
Journal of the National Cancer Institute, Vol. 99, nr 7. 4 April 2007
For further information: Dr Katja Fall Tel: +46 (0)8-5248 6109 or +46 (0)709-221974 (mobile) Email: email@example.com Press Officer Sabina Bossi Tel: +46 (0)8-524 860 66 Email: Sabina.firstname.lastname@example.org
Katarina Sternudd | idw
How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine
Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
22.01.2018 | Materials Sciences
22.01.2018 | Earth Sciences
22.01.2018 | Life Sciences