Dr Reidun Twarock, an Anniversary Reader in the Departments of Biology and Mathematics, will study the structure and assembly of viruses, which will help to develop new anti-viral strategies.
Viruses have highly symmetrical external shells formed from proteins that encapsulate the viral genome. Dr Twarock has developed a method for encoding the structures of these protein shells that pinpoint the locations of the proteins and the bonds between them. With collaborators Professor Cristian Micheletti, from the International School for Advanced Studies (SISSA) in Trieste, Italy, and Professor Anne Taormina, from the University of Durham, she has used these results to model the assembly of viruses.
Subsequent work with collaborators Professor Peter Stockley, Dr Neil Ranson and their groups at the Astbury Centre for Structural Molecular Biology at the University of Leeds suggests that not only the geometry of the viral capsids themselves but also the full three-dimensional structures of the particles are constrained. The implications of this discovery on virus assembly are currently being investigated.
Dr Twarock said: “I would like to use the Leverhulme Trust Award to build up a group of mathematicians, computational biologists and biophysicists to address a portfolio of projects arising from these results.”
This grant will enable Dr Twarock to expand her group and fund three postdoctoral positions and four PhD students. The group will collaborate closely with the Astbury Centre in Leeds, and they will jointly organise a workshop on Mathematical Virology at the International Centre for Mathematical Sciences in August 2007.
Dr Twarock’s group will be part of the York Centre of Complex Systems Analysis (YCCSA), including biologists, mathematicians and computer scientists, which is based in the Department of Biology at York.
Nicola Coates | alfa
'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers
16.02.2018 | National University of Science and Technology MISIS
New process allows tailor-made malaria research
16.02.2018 | Eberhard Karls Universität Tübingen
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
20.02.2018 | Life Sciences
20.02.2018 | Medical Engineering
20.02.2018 | Physics and Astronomy