Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Diabetes Risk Factors Develop Earlier in Women than Men

22.02.2007
The "diabetes clock" may start ticking in women years in advance of a medical diagnosis of the disease, new research has shown.

Epidemiologists at the University at Buffalo have found that newly identified risk factors for diabetes found in the blood, such as markers of endothelial dysfunction, chronic sub-acute inflammation and blood clotting factors, are present early on in women who eventually progress from normal glucose status to the pre-diabetic condition.

Pre-diabetes is diagnosed when blood sugar levels are higher than normal (between 100-125 mg/deciliter of blood), but not high enough to indicate full-blown diabetes (over 125 mg/deciliter of blood). The markers weren't associated with progression from normal to pre-diabetic status in men.

Results of the study appear in the February 2007 issue of Diabetes Care.

"This is one of the first reports to show that otherwise healthy women are more likely than men to show elevated levels of endothelial factors and other markers of progression to pre-diabetes," said lead author Richard Donahue, Ph.D., professor of social and preventive medicine and associate dean for research in UB's School of Public Health and Health Professions.

"Because these pre-diabetic markers are not routinely assessed, and because diabetes is strongly linked with coronary heart disease, the study may help explain why the decline in death rates for heart disease in diabetic women lags behind that of diabetic men," he said.

"Previous research had shown that hypertension and cholesterol were elevated among women who later developed diabetes. However, current findings that these novel risk factors [markers of endothelial dysfunction, chronic sub-acute inflammation and blood clotting factors] are elevated among women even earlier than previously recognized does suggest that the 'diabetes clock' starts ticking sooner for women than for men."

The study involved 1,455 healthy participants originally enrolled in the Western New York Study, a case-control investigation of patterns of alcohol consumption and risk of cardiovascular disease conducted from 1996-2001. In the current study all participants were free of pre-diabetes, type 2 diabetes and known cardiovascular disease. They received a physical examination when they entered the study and again for this six-year follow-up.

Standard measures -- height, weight, waist girth, blood pressure -- were taken, plus blood samples to determine concentrations of fasting glucose and insulin, specific proinflammatory markers, C-reactive protein and markers of dysfunction in the endothelial tissue, the tissue lining blood vessels.

Results showed that 52 women and 39 men had progressed from normal blood glucose levels to pre-diabetic status during the previous six years.

Donahue said the question of what explains the sex difference remains to be determined, and he plans to study this in the future. Meanwhile, he suggested that women whose blood glucose increases over time, even if it doesn't reach diabetic levels, should be screened more intensively for cardiovascular disease.

Karol Rejman, Lisa Rafalson, Jacek Dmochowski, Ph.D., Saverio Stranges, M.D., Ph.D., and Maurizio Trevisan, M.D., all from the UB Department of Social and Preventive Medicine, contributed to the study. Dmochowski also is affiliated with the University of North Carolina, Charlotte.

The research was supported by a grant from the National Institutes of Health.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. The School of Public Health and Health Professions is one of five schools that constitute UB's Academic Health Center.

Lois Baker | EurekAlert!
Further information:
http://www.buffalo.edu

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>