Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


CRP liver protein induces hypertension

C-Reactive Protein, widely regarded as a risk factor for hypertension and other forms of cardiovascular disease, plays a direct role in the onset of hypertension, researchers at UT Southwestern Medical Center have found.

"We have discovered that C-Reactive Protein (CRP) is not merely a marker of the risk of hypertension, it actually induces hypertension," said Dr. Wanpen Vongpatanasin, associate professor of internal medicine and lead author of the study appearing in the February issue of Circulation.

UT Southwestern researchers studied mice with an engineered gene for CRP that was under the regulation of a second gene responsive to changes in dietary carbohydrate intake. The levels of circulating CRP, which is produced by the liver, were directly manipulated by altering the mice's diets, and the effect on blood pressure was determined. In this manner the actions of CRP were segregated from the actions of other mediators of inflammation.

"We found that when we switched on the gene that causes increases in CRP, the blood pressure went up, and when we turned off the gene and CRP levels went down, the blood pressure fell. Diet changes in the control mice had no effect, indicating that the blood pressure responses were due to CRP," said Dr. Vongpatanasin. "The cause of elevated blood pressure induced by CRP was also determined."

Clinical studies over the past decade have suggested that chronically elevated levels of CRP indicate inflammation that puts an individual at risk for hypertension and other cardiovascular ailments such as hardening of the arteries.

The mice in the latest study were supersensitive to angiotensin II, which is a major circulating factor regulating blood pressure via arterial constriction. This was due to alterations in key proteins in the vascular wall that are involved with angiotensin II.

Also, the researchers discovered that the initiating mechanism is a lack of the key signaling molecule nitric oxide in the artery wall, which has multiple beneficial roles in the cardiovascular system, as well as made a connection between nitric oxide and the proteins responsible for angiotensin II activity.

"Whether these same processes are operative in humans is yet to be determined," said Dr. Vongpatanasin. "We are also pursuing follow-up studies to further understand better how CRP causes the high blood pressure in the mice."

The ultimate goal of the research is to discover how CRP interacts with molecules in the artery wall, leading to a better understanding of hypertension and pointing to new ways to treat it, Dr. Vongpatanasin said.

"We have uncovered a series of mechanisms that link a circulating factor that rises with chronic inflammation, obesity and aging to the regulation of blood pressure," said Dr. Philip Shaul, professor of pediatrics at UT Southwestern and the study's senior author. "Doing so provides a new perspective on how these conditions have a negative impact on cardiovascular health."

Katherine Morales | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

nachricht Breakthrough in Mapping Nicotine Addiction Could Help Researchers Improve Treatment
04.10.2016 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Innovative technique for shaping light could solve bandwidth crunch

20.10.2016 | Physics and Astronomy

Finding the lightest superdeformed triaxial atomic nucleus

20.10.2016 | Physics and Astronomy

NASA's MAVEN mission observes ups and downs of water escape from Mars

20.10.2016 | Physics and Astronomy

More VideoLinks >>>