It's the most common bacteria-related sexually transmitted disease in the United States, so researchers at The University of Texas at San Antonio's South Texas Center for Emerging Infectious Diseases (STCEID) and The University of Texas at San Antonio Health Science Center have partnered to discover a vaccine that will prevent Chlamydia.
According to the Centers for Disease Control and Prevention (CDC), Chlamydia is a common sexually transmitted disease caused by the bacterium, Chlamydia trachomatis, which can damage a woman's reproductive organs. In women, symptoms are usually mild or absent. Serious complications can cause irreversible damage, including infertility, before a woman ever recognizes a problem. In men, Chlamydia complications can also cause discharge from the penis of an infected male.
The most recent report from the CDC indicates 930,000 cases of Chlamydial infection were reported in the United States in 2004. It's estimated annually, that the number of new cases of Chlamydia infection has risen to more than 2.8 million.
After three years of trial-and-error, Ashlesh Murthy, a post-doctoral student in the UTSA Cell and Molecular Biology program has found success in administering a chlamydial prevention vaccine in mouse models. The next step will be to test the vaccine in larger animals, primarily guinea pigs.
"This is a very prevalent disease in women throughout the world and the biggest problem is that most infected women never show any symptoms, so they never get treated," said Murthy. "When Chlamydia is left untreated, it can lead to severe complications including pelvic-inflammatory disease, ectopic pregnancies and infertility."
Murthy's research is guided by Bernard Arulanandam, an associate professor of biology who began studying Chlamydia six years ago.
"With the recent success of the human papilloma virus vaccine, developed to prevent cervical cancer in young women, I think the urgency to develop a Chlamydia prevention vaccine is on the horizon," said Arulanandam.
The UTSA researchers have been working with Guangming Zhong, a professor of microbiology at UTHSC, whose lab has been identifying antigens or proteins in Chlamydia as vaccine candidates and providing them for the UTSA researchers to analyze for their efficacy.
Kris Edward Rodriguez | EurekAlert!
Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin
Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....
Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
24.05.2017 | Event News
23.05.2017 | Event News
22.05.2017 | Event News
26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy