The license, which was granted following months of strict safety testing and evaluation by the Medicines and Healthcare Products Regulatory Authority (MHRA), allows the Centre to manufacture PET (Positron Emission Tomography) tracers in its high-tech sterile facilities and administer them to human participants in clinical trials. The license is one of only a handful issued in the UK.
PET scanning produces high-resolution images of internal organs and biological processes at work by injecting trace amounts of a radioactive compound, or ‘radiotracer’, into the part of the body to be scanned. Radioactive emissions from this tracer are then recorded by detectors within the scanner, and the resulting data processed by sophisticated software to create the images.
The trace levels of radioactivity are closely monitored for the safety of the patient, and diminish after a short time.
The license means the Centre can now develop, manufacture and use more complex radiotracers, such as those derived from the element Carbon-11 (11C). These will allow researchers to measure a wide range of complex molecular events such as cancer tumour growth, cell death, psychoses and chronic pain, as well as the effect of drugs designed to treat these conditions.
Such PET studies using advance tracers look set to inspire breakthroughs in research and improve the treatment of patients. The first to be enabled will investigate a possible link between inflammation in the central nervous system (CNS) and increased risk of stroke.
Lead researcher Dr Pippa Tyrrell of the University’s School of Medicine said: “This license means we can now measure CNS inflammation in subjects we know have an increased risk of stroke*, using one of the new tracers to detect activated immune cells in their brains. Around 125,000 people are affected by stroke each year in the UK and this approach could uncover vital new evidence on the role of inflammation; helping us to understand the risk factors and potentially modulate them.”
Ian Young, Quality Manager for the Centre, said “The MHRA’s requirements are very exacting and creating the extensive quality management system which has allowed us to progress to this level has involved a huge effort from all staff.”
Its Director Professor Karl Herholz said: “The award of this license is a key strategic milestone for the Centre, as we can now progress with the molecular imaging projects it is uniquely equipped to carry out. This approach to better-understanding the mechanisms of both the brain and cancer tumours is relatively under-explored, and we are very excited about its potential to inspire breakthroughs and improve patient treatments.”
Jon Keighren | alfa
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
27.04.2017 | Life Sciences
27.04.2017 | Physics and Astronomy
27.04.2017 | Earth Sciences