Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Medical researchers get green light on radioactive ‘tracers’

18.01.2007
The Wolfson Molecular Imaging Centre at The University of Manchester has been awarded a license to produce its own radioactive tracers, enabling it to proceed with unique research into cancer, neurological and psychiatric treatments.

The license, which was granted following months of strict safety testing and evaluation by the Medicines and Healthcare Products Regulatory Authority (MHRA), allows the Centre to manufacture PET (Positron Emission Tomography) tracers in its high-tech sterile facilities and administer them to human participants in clinical trials. The license is one of only a handful issued in the UK.

PET scanning produces high-resolution images of internal organs and biological processes at work by injecting trace amounts of a radioactive compound, or ‘radiotracer’, into the part of the body to be scanned. Radioactive emissions from this tracer are then recorded by detectors within the scanner, and the resulting data processed by sophisticated software to create the images.

The trace levels of radioactivity are closely monitored for the safety of the patient, and diminish after a short time.

The license means the Centre can now develop, manufacture and use more complex radiotracers, such as those derived from the element Carbon-11 (11C). These will allow researchers to measure a wide range of complex molecular events such as cancer tumour growth, cell death, psychoses and chronic pain, as well as the effect of drugs designed to treat these conditions.

Such PET studies using advance tracers look set to inspire breakthroughs in research and improve the treatment of patients. The first to be enabled will investigate a possible link between inflammation in the central nervous system (CNS) and increased risk of stroke.

Lead researcher Dr Pippa Tyrrell of the University’s School of Medicine said: “This license means we can now measure CNS inflammation in subjects we know have an increased risk of stroke*, using one of the new tracers to detect activated immune cells in their brains. Around 125,000 people are affected by stroke each year in the UK and this approach could uncover vital new evidence on the role of inflammation; helping us to understand the risk factors and potentially modulate them.”

Ian Young, Quality Manager for the Centre, said “The MHRA’s requirements are very exacting and creating the extensive quality management system which has allowed us to progress to this level has involved a huge effort from all staff.”

Its Director Professor Karl Herholz said: “The award of this license is a key strategic milestone for the Centre, as we can now progress with the molecular imaging projects it is uniquely equipped to carry out. This approach to better-understanding the mechanisms of both the brain and cancer tumours is relatively under-explored, and we are very excited about its potential to inspire breakthroughs and improve patient treatments.”

Jon Keighren | alfa
Further information:
http://www.manchester.ac.uk/aboutus/news/

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>