Hypertension and prehypertension in adolescents and young adults was associated with a higher risk of having an abnormally enlarged heart, researchers report in Circulation: Journal of the American Heart Association.
In a study of American Indians, average age 26.5, those with hypertension or prehypertension were more likely to have changes in the heart structure associated with increased cardiovascular risk: higher left ventricular wall thickness, higher left ventricular mass and higher prevalence of left ventricular hypertrophy. The prevalence of left ventricular hypertrophy was three times higher among those with hypertension and two times higher among those with prehypertension, compared to those with normal blood pressure.
Left ventricular hypertrophy is an abnormal thickening of the muscles of the heart's left ventricle (main pumping chamber). It is associated with heart and blood vessel complications, such as heart failure.
"The findings are a wake-up call for increased preventive measures to head off heart disease with lifestyle modifications, such as reducing caloric intake and increasing physical activity in this population," said Richard B. Devereux, M.D., senior study author and professor of medicine at Weill Medical College of Cornell University in New York City.
"At these younger ages, the increasing prevalence of early-onset hypertension and prehypertension is associated with changes in the heart that are related to worsened prognosis for heart disease, disability and death," he said.
Prehypertension is defined as systolic blood pressure higher than 120 mmHg but lower than 140 mmHg, or a diastolic pressure greater than 80 mmHg but lower than 90 mmHg, or both. Hypertension is defined as a systolic blood pressure greater than 140 mmHg or a diastolic blood pressure greater than 90 mmHg. Prehypertension is a relatively new category of blood pressure established by the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC-7). Devereux said this is the first large population-based study to examine the heart changes associated with the new JNC-7 category of hypertension.
"Previous research has found little difference comparing middle-aged to elderly overweight hypertensive white, black and American-Indian adults, suggesting that Indian populations are not unique, and may provide a preview of what other populations may experience as overweight and obesity rates increase," he said.
Researchers analyzed the association of prehypertension and early-onset hypertension with clinical characteristics and changes in heart structure and function in 1,944 participants (57.5 percent women) of the Strong Heart Study, an ongoing study of cardiovascular risk factors and disease in 13 American-Indian communities.
In data collected from health examinations conducted between July 2001 and September 2003, researchers found early-onset hypertension in 294 participants (15 percent) and prehypertension in 675 participants (35 percent).
Both hypertensive and prehypertensive participants were more likely to be men, obese, have diabetes, and have impaired fasting glucose. Hypertensive and prehypertensive participants had higher average pulse pressure (the difference between systolic and diastolic blood pressure values), stroke volume index (related to the volume of blood the heart pumps out at each beat), and total peripheral resistance index (a reflection of how constricted peripheral blood vessels are – peripheral constriction causes blood pressure to rise). There was an early prevalence of increased arterial stiffness with multiple features related to insulin resistance.
"The frequency of heart abnormalities in these younger participants is similar to that found in the middle-age or adult population of hypertensives who are at risk for adverse events," Devereux said.
Jennifer S. Drukteinis, M.D., lead author of the study and an internal medicine resident at Weill Medical College of Cornell University, said the implications are clear: "There needs to be vigilant monitoring of blood pressure at younger and younger ages. Obesity and high blood pressure go hand-in-hand, and lifestyle modification is the key."
Karen Astle | EurekAlert!
Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
18.10.2017 | Materials Sciences
18.10.2017 | Physics and Astronomy
18.10.2017 | Physics and Astronomy