Researchers at Rush University Medical Center found that having complaints about memory problems is associated with changes in the brain related to Alzheimer’s disease. They reported their findings in the November 2006 issue of Neurology.
The researchers looked at the association between memory problems reported by study participants and signs of disease found in their brains after death. The study looked at autopsies of 90 older adults from the Rush Memory and Aging Project. The study included both participants who had been diagnosed with Alzheimer’s disease (23) and those that showed no clinical signs of the disease (67).
“One of the most interesting findings of the study was that individuals who had yet to have any clinical symptoms of Alzheimer’s disease still showed a strong link between their self-reported memory complaints and brain pathology associated with Alzheimer’s disease,” said Lisa L. Barnes, PhD, from the Rush Alzheimer’s Disease Center. “This information may allow us to use memory complaints as a measure to intervene at an early point in the disease process.”
To measure memory complaints participants were asked two questions:- How often do you have trouble remembering things?
The researchers then compared this scale with the levels of damage to the brain revealed during autopsy. The damage specifically looked at was the amount of amyloid plaques and tau tangles in the brain at the time of death. These plaques and tangles are the type of damage most closely linked to Alzheimer’s disease.
The researchers found that each unit of Alzheimer-related pathology was associated with one point higher score on the memory complaint scale. “Our results suggest that older persons with and without dementia possess some insight to their level of functioning, and this insight is related to actual changes in the brain,” said Barnes. “The data suggests that if you’re having complaints there’s probably something going on. In other words, if mom notices that there’s something different about her memory, we need to listen closely and investigate further.”
The study shows that memory complaints should be taken seriously and not seen as just part of the aging process. “In my opinion, it is possible to preserve your memory into old age,” said Barnes. “Memory loss is not an inevitable consequence of aging.
In fact, if you think you are having memory problems, you should probably see your doctor. As Barnes noted, “although not all memory complaints will lead to Alzheimer’s disease, our data support the idea that memory complaints in older adults may represent the presence of significant Alzheimer’s disease pathology in the brain.”
“I don’t want to cause concern for people who experience occasional memory loss, like losing their keys or forgetting their wife’s birthday,” said Barnes. “The important point in our study was that the people who hadn’t developed Alzheimer’s disease by the time they died, but complained about their memory performance, already had Alzheimer’s pathology in their brains. We don’t know whether they might have eventually developed the disease had they lived longer. The data suggest, however, that memory complaints may be an early sign of disease in some people.”
The researchers at Rush are grateful for the remarkable dedication and altruism of the volunteers participating in the Rush Memory and Aging Project. The research was supported by grants from the National Institute on Aging, which leads the Federal effort to support and conduct basic, clinical, and social and behavioral studies on aging and on Alzheimer’s disease.
Mary Ann Schultz | EurekAlert!
Indications of Psychosis Appear in Cortical Folding
26.04.2018 | Universität Basel
GLUT5 fluorescent probe fingerprints cancer cells
20.04.2018 | Michigan Technological University
Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...
At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.
Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
26.04.2018 | Power and Electrical Engineering
26.04.2018 | Life Sciences
26.04.2018 | Power and Electrical Engineering