"The findings are promising as spinal cord injury pain is a condition which generally responds poorly to currently available treatments," said study author Philip J. Siddall, MBBS, PhD, with Royal North Shore Hospital in Sydney, Australia.
The study, considered to be the largest randomized controlled trial of spinal cord injury patients with nerve pain, involved 137 adults in Australia over a 12-week period. Half of the group received pregabalin; the other half received a placebo.
Researchers found at the end of 12 weeks, fewer than 16 percent of patients taking pregabalin had severe pain compared with 43 percent in the placebo group. And over one-third of patients in the pregabalin group had no or mild pain.
The study also found pregabalin reduced sleep and anxiety problems compared to the placebo group.
"Pregabalin was significantly more effective in relieving pain, improving sleep, anxiety, and overall well-being in patients with spinal cord injury compared to placebo," said Siddall. "Fifty-seven percent of patients taking pregabalin said they felt better overall compared to 21 percent in the placebo group."
Siddall said the pain relief was rapid as the pregabalin group had significant pain relief after the first week of the study. The drug's most common side effects were dizziness and drowsiness.
Nerve pain is estimated to occur in up to 40 percent of people with spinal cord injury. According to the National Spinal Cord Injury Association, as many as 450,000 people in the United States have spinal cord injuries and about 11,000 people sustain new spinal cord injuries each year.
Angela Babb | EurekAlert!
Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku
Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.
In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...
A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.
By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...
Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
23.02.2018 | Physics and Astronomy
23.02.2018 | Health and Medicine
23.02.2018 | Physics and Astronomy